Copper(II)-catalyzed C3-acylation of quinoxalin-2(1H)-ones with methyl ketones via the formal decarbonylation of 1,2-diketones.

IF 2.8 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2026-10-07 DOI:10.1039/d6ob01048b

Raju Lal Dhakar, Pundalik Baliram Polawad, Hritik Prakash Kaushal, Patel Kevin Bhanubhai, S Banuprakash Goud, Sampak Samanta

引用次数: 0

Abstract

The inexpensive copper(II) bromide-catalyzed cross-dehydrogenative coupling/Kornblum oxidation/formal decarbonylation of N-substituted/unsubstituted quinoxalinones in DMSO is reported. It has offered a new technique for the cleavage of C(CO)-C(CO) bonds under base- and ligand-free conditions, allowing for the direct synthesis of a diverse range of C3-acylated quinoxalinones. This persulfate-peroxide-free catalytic method provides good yields, a broad substrate scope, and good tolerance to various functionalities.

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铜（II）催化喹啉-2(1H)- 1通过1,2-二酮的形式脱羰化与甲基酮的c3酰化。

报道了溴化铜在DMSO中催化n -取代/未取代喹啉酮的低成本交叉脱氢偶联/Kornblum氧化/正式脱羰反应。它提供了一种在无碱和无配体条件下裂解C(CO)-C（CO）键的新技术，从而可以直接合成各种c3酰化喹诺啉酮。这种无过硫酸盐-过氧化物的催化方法具有良好的产率，广泛的底物范围和对各种功能的良好耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.