Pyridones and macrocyclic pyrrolidones from marine fungal PKS-NRPS hybrids: biosynthetic origin, bioactivities, and synthetic advances.

IF 12.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2026-09-21 DOI:10.1039/d6np00050a

Ning Gao, Felix Boahen Owusu, Jiewen Yu, Fa-Liang An, Xu-Wen Li

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引用次数: 0

Abstract

Covering: 2002-2025Marine fungi have emerged as a prolific source of structurally unprecedented and biologically potent secondary metabolites, and hybrid polyketide synthase-non-ribosomal peptide synthase (PKS-NRPS) enzymes mainly from marine fungi like symbiotic Aspergillus and deep-sea Penicillium, represent an exceptionally fertile source of such complex natural products. Among the diverse products of these mega-enzymes, pyridones and macrocyclic pyrrolidone constitute a unique class of natural products with significant therapeutic potential. This review provides a comprehensive overview on this family of natural products, covering their global distribution and biosynthetic enzymology, chemical ecology, and biosynthesis. The bioactivities of these compounds, ranging from potent anticancer and antibacterial to immunosuppressive and anti-inflammatory effects, are discussed. Furthermore, this review summarises the synthetic strategies developed to access these complex chemical scaffolds. This review provides a roadmap for future genome-guided discovery and the rational design of novel therapeutics inspired by these privileged marine natural products.

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海洋真菌PKS-NRPS杂种的吡啶酮和大环吡咯烷酮：生物合成来源、生物活性和合成进展。

海洋真菌已经成为结构上前所未有的、生物上有效的次生代谢物的丰富来源，而主要来自共生曲霉和深海青霉等海洋真菌的杂合多酮合成酶-非核糖体肽合成酶（PKS-NRPS）酶代表了这种复杂天然产物的异常丰富的来源。在这些大型酶的多种产物中，吡啶酮和大环吡咯烷酮构成了一类独特的天然产物，具有显著的治疗潜力。本文综述了该家族天然产物的全球分布、生物合成酶学、化学生态学和生物合成等方面的研究进展。讨论了这些化合物的生物活性，从有效的抗癌和抗菌到免疫抑制和抗炎作用。此外，本文综述了获取这些复杂化学支架的合成策略。这一综述为未来的基因组引导发现和合理设计由这些特殊的海洋天然产物启发的新疗法提供了路线图。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.