Global Postural Reeducation in Mild Alzheimer's Disease: A Secondary Analysis of an RCT.

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-09-18 DOI:10.1177/15333175261489372

Orges Lena, Jasemin Todri

{"title":"Global Postural Reeducation in Mild Alzheimer's Disease: A Secondary Analysis of an RCT.","authors":"Orges Lena, Jasemin Todri","doi":"10.1177/15333175261489372","DOIUrl":null,"url":null,"abstract":"<p><p>BackgroundDepression and neuropsychiatric symptoms are common in Alzheimer's disease (AD) and may contribute to functional decline and reduced quality of life.MethodsThis secondary analysis used data from a randomized controlled trial (NCT03732053). Fifty-eight participants were analyzed: 36 received supervised GPR twice weekly for 24 weeks and 22 received usual care. Outcomes included the Geriatric Depression Scale (GDS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Barthel Index, and Performance-Oriented Mobility Assessment (POMA). Repeated-measures ANOVA and baseline-adjusted analyses were performed.ResultsAt 24 weeks, GDS scores were lower with GPR than usual care (4.72 ± 2.36 vs. 8.41 ± 2.15; p < 0.001). Significant group × time effects were observed for NPI, MMSE, Barthel Index, and POMA (all p < 0.001).ConclusionGPR may provide complementary benefits across psychological, cognitive, and functional outcomes in mild AD, although baseline imbalance and differential attrition warrant cautious interpretation.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261489372"},"PeriodicalIF":2.7000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of Alzheimer's disease and other dementias","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/15333175261489372","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/9/18 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

BackgroundDepression and neuropsychiatric symptoms are common in Alzheimer's disease (AD) and may contribute to functional decline and reduced quality of life.MethodsThis secondary analysis used data from a randomized controlled trial (NCT03732053). Fifty-eight participants were analyzed: 36 received supervised GPR twice weekly for 24 weeks and 22 received usual care. Outcomes included the Geriatric Depression Scale (GDS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Barthel Index, and Performance-Oriented Mobility Assessment (POMA). Repeated-measures ANOVA and baseline-adjusted analyses were performed.ResultsAt 24 weeks, GDS scores were lower with GPR than usual care (4.72 ± 2.36 vs. 8.41 ± 2.15; p < 0.001). Significant group × time effects were observed for NPI, MMSE, Barthel Index, and POMA (all p < 0.001).ConclusionGPR may provide complementary benefits across psychological, cognitive, and functional outcomes in mild AD, although baseline imbalance and differential attrition warrant cautious interpretation.

查看原文本刊更多论文

轻度阿尔茨海默病的整体体位再教育：一项随机对照试验的二次分析。

抑郁和神经精神症状在阿尔茨海默病（AD）中很常见，可能导致功能下降和生活质量下降。方法该二次分析数据来自一项随机对照试验（NCT03732053）。对58名参与者进行分析：36名接受监督GPR，每周两次，持续24周，22名接受常规护理。结果包括老年抑郁量表（GDS）、神经精神量表（NPI）、迷你精神状态检查（MMSE）、Barthel指数（Barthel Index）和绩效导向活动能力评估（POMA）。进行重复测量方差分析和基线校正分析。结果24周时，GPR组GDS评分低于常规护理组（4.72±2.36∶8.41±2.15;p < 0.001）。NPI、MMSE、Barthel指数和POMA均观察到显著的组×时间效应（p < 0.001）。结论：尽管基线失衡和差异消耗值得谨慎解释，但在轻度AD患者中，ongpr可能在心理、认知和功能结局方面提供互补益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American journal of Alzheimer's disease and other dementias

自引率

0.00%

发文量