{"title":"Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance (5/2026)","authors":"Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu","doi":"10.1002/inmd.70174","DOIUrl":null,"url":null,"abstract":"<p>This cover depicts an upward-looking abyssal scene. Copper-dark gold pathogenic bacteria twine around glowing immune cells, illustrating that harmful intratumoral bacteria lead to T cell exhaustion and immunotherapy resistance. Clustered pathogens form shadow silhouettes to represent tumor immune escape. The light shining down from the top symbolizes therapeutic strategies: removing harmful bacteria and utilizing beneficial microbes as well as their metabolites to restore anti-tumor immunity. The image straightforwardly demonstrates the bidirectional interactions between intratumoral microbes, tumor cells and immune cells, showcasing interdisciplinary research on cancer immunotherapy.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 5","pages":""},"PeriodicalIF":13.6000,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70174","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interdisciplinary Medicine","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/inmd.70174","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
This cover depicts an upward-looking abyssal scene. Copper-dark gold pathogenic bacteria twine around glowing immune cells, illustrating that harmful intratumoral bacteria lead to T cell exhaustion and immunotherapy resistance. Clustered pathogens form shadow silhouettes to represent tumor immune escape. The light shining down from the top symbolizes therapeutic strategies: removing harmful bacteria and utilizing beneficial microbes as well as their metabolites to restore anti-tumor immunity. The image straightforwardly demonstrates the bidirectional interactions between intratumoral microbes, tumor cells and immune cells, showcasing interdisciplinary research on cancer immunotherapy.
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