Cardiovascular Disease and Androgens: Clinical Trends, Potential Mechanisms, and Considerations for Engineering Solutions.

IF 2.4 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Engineering and Technology Pub Date : 2026-09-17 DOI:10.1007/s13239-026-00859-5

Madeline N Monroe, Alexander L Curylo, Farshad Amirkhosravi, Eric I Garcia Huitron, George I Ezeokeke, Inioluwa G Ojediran, Jessica K Wang, Sawyer E Cremer, K Jane Grande-Allen

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Abstract

This review summarizes the current understanding of androgen physiology, relationships between androgens and cardiovascular (CV) diseases, and novel engineering approaches to study the effect of androgens on CV system. Testosterone (T), the primary sex hormone in biological males and a potent sex hormone in females, is the androgen of focus for this review. In the cardiovascular system, T signaling is seen through varying genomic and non-genomic mechanisms, which are further detailed in this review. Varying androgen levels in aging adults can significantly impact CVD outcomes, particularly for males. We also consider the implication of exogenous T treatment and androgen deprivation treatments on CVD. Furthermore, androgen-related trends in different CVD processes such as cardiac hypertrophy, congestive heart failure, atherosclerosis, calcific aortic valve disease, and aneurysms are explored. To that end, we present opportunities for novel tissue engineered approaches to discovering mechanisms and potential therapeutic pathways for androgen-related CV conditions.

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心血管疾病和雄激素：临床趋势、潜在机制和工程解决方案的考虑。

本文综述了目前对雄激素生理学的认识、雄激素与心血管疾病的关系以及研究雄激素对心血管系统影响的新工程方法。睾酮(T)是生物学上男性的主要性激素，也是女性的一种强有力的性激素，是本综述的重点。在心血管系统中，T信号通过不同的基因组和非基因组机制被观察到，这将在本文中进一步详细介绍。老年人雄激素水平的变化会显著影响心血管疾病的预后，尤其是男性。我们还考虑了外源性T治疗和雄激素剥夺治疗对心血管疾病的影响。此外，我们还探讨了雄激素在不同心血管疾病过程中的相关趋势，如心脏肥厚、充血性心力衰竭、动脉粥样硬化、钙化主动脉瓣疾病和动脉瘤。为此，我们提出了新的组织工程方法来发现雄激素相关心血管疾病的机制和潜在的治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Engineering and Technology Engineering-Biomedical Engineering

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Cardiovascular Engineering and Technology is a journal publishing the spectrum of basic to translational research in all aspects of cardiovascular physiology and medical treatment. It is the forum for academic and industrial investigators to disseminate research that utilizes engineering principles and methods to advance fundamental knowledge and technological solutions related to the cardiovascular system. Manuscripts spanning from subcellular to systems level topics are invited, including but not limited to implantable medical devices, hemodynamics and tissue biomechanics, functional imaging, surgical devices, electrophysiology, tissue engineering and regenerative medicine, diagnostic instruments, transport and delivery of biologics, and sensors. In addition to manuscripts describing the original publication of research, manuscripts reviewing developments in these topics or their state-of-art are also invited.