Cervical, Uterine, and Ovarian Cancers in Chinese Women Aged 55 Years and Older: Burden, Temporal Trends, Risk Attribution, and Future Projections From the Global Burden of Disease Study 2021

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2026-09-17 DOI:10.1111/jog.70413

Xin Zhang, Tao Zhu, Zhan Gao, Zhenhui Han, Shang Zheng

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引用次数: 0

Abstract

Aim

To compare the burden, temporal trends, risk factor attribution, and future projections of cervical, uterine, and ovarian cancers among Chinese women aged 55 years and older.

Methods

We conducted a population-based descriptive and projection analysis using data from the Global Burden of Disease Study 2021. Incidence, mortality, disability-adjusted life years (DALYs), and corresponding age-standardized rates for cervical, uterine, and ovarian cancers were extracted for 1990–2021. Age-specific burden, temporal trends, and attributable risk factors were examined. Incidence and mortality from 2022 to 2036 were projected using a Bayesian age-specific trend model.

Results

From 1990 to 2021, the absolute numbers of incident cases, deaths, and DALYs increased for all three cancers among Chinese women aged 55 years and older, whereas age-standardized mortality and DALY rates generally declined. In 2021, cervical cancer showed the highest overall burden, with mortality rates increasing markedly in the oldest age groups. Uterine cancer showed the largest increase in incidence age-standardized rate and a burden concentrated mainly in the younger segment of older women. Ovarian cancer showed a relatively unfavorable mortality pattern and was projected to have increasing incidence and mortality through 2036. Risk attribution differed by cancer type: cervical cancer mortality was mainly attributable to unsafe sex, uterine cancer mortality to high body mass index, and ovarian cancer mortality to mixed metabolic and environmental or occupational risks.

Conclusion

Cervical, uterine, and ovarian cancers remain substantial and heterogeneous health burdens among older Chinese women. Despite declines in age-standardized mortality and DALY rates, population aging is likely to increase the absolute burden. Age-specific prevention, screening, early detection, and resource allocation are needed for older women in China.

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中国55岁及以上女性的宫颈癌、子宫癌和卵巢癌：负担、时间趋势、风险归因和来自2021年全球疾病负担研究的未来预测

目的：比较55岁及以上中国女性宫颈癌、子宫癌和卵巢癌的负担、时间趋势、危险因素归因和未来预测。方法：我们使用2021年全球疾病负担研究的数据进行了基于人群的描述性和预测分析。提取1990-2021年宫颈癌、子宫癌和卵巢癌的发病率、死亡率、残疾调整生命年（DALYs）和相应的年龄标准化率。研究了年龄特异性负担、时间趋势和归因风险因素。使用贝叶斯年龄趋势模型预测2022年至2036年的发病率和死亡率。结果：从1990年到2021年，55岁及以上的中国女性中所有三种癌症的绝对病例数、死亡人数和DALY都有所增加，而年龄标准化死亡率和DALY率普遍下降。2021年，宫颈癌的总体负担最高，年龄最大年龄组的死亡率显著上升。子宫癌发病率的年龄标准化率增幅最大，负担主要集中在老年妇女的年轻部分。卵巢癌显示出相对不利的死亡率模式，预计到2036年发病率和死亡率都将增加。风险归因因癌症类型而异：宫颈癌死亡主要归因于不安全性行为，子宫癌死亡主要归因于高体重指数，卵巢癌死亡主要归因于代谢和环境或职业混合风险。结论：宫颈癌、子宫癌和卵巢癌仍然是中国老年妇女的主要和异质性健康负担。尽管年龄标准化死亡率和DALY率有所下降，但人口老龄化可能会增加绝对负担。中国老年妇女需要针对不同年龄的预防、筛查、早期发现和资源分配。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.