Per- and polyfluoroalkyl substances levels other than PFOS, PFOA, or PFHxS and liver cancer risk: a nested case-control analysis.

IF 7.7 1区医学 Q1 ONCOLOGY

JNCI Journal of the National Cancer Institute Pub Date : 2026-09-17 DOI:10.1093/jnci/djag325

Cody Z Watling, Jessica L Petrick, Barry I Graubard, Hyokyoung G Hong, Xuehong Zhang, Matthew J Barnett, Mollie E Barnard, Yu Chen, A Heather Eliassen, J Michael Gaziano, Wen-Yi Huang, Jae H Kang, Jill Koshiol, I-Min Lee, Erikka Loftfield, Steven C Moore, Lorelei A Mucci, Marian L Neuhouser, Christina C Newton, Howard D Sesso, Martha Shrubsole, Rashmi Sinha, Lesley Tinker, Matthew Triplette, Caroline Y Um, Kala Visvanathan, Jean Wactawski-Wende, Eleanor L Watts, Walter C Willett, Fen Wu, Wei Zheng, Peter T Campbell, Jonathan N Hofmann, Mark P Purdue, Dinesh Barupal, Katherine A McGlynn

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引用次数: 0

Abstract

Epidemiologic studies of PFAS and liver cancer risk have produced conflicting results with no strong or clear associations for pre-diagnostic perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS). We now report analyses of nine additional PFAS in a nested case-control study within 12 prospective cohorts (853 cases, 853 matched controls) in the United States. Using multivariable-adjusted conditional logistic regression, we estimated odds ratios per 90th vs. 10th percentile increase in PFAS levels. Perfluoroheptanoic acid (PFHpA) was positively associated with liver cancer risk (OR: 1.78, 95% CI: 1.26-2.52); no associations were observed for other PFAS. Significant heterogeneity was observed by sex, cancer subtype, and time from blood collection. Associations were stronger among males (OR: 3.72, 95% CI: 2.10-6.59), for hepatocellular carcinoma (4.53, 2.59-7.94), and for those diagnosed ≤10 years after blood collection (3.17, 1.80-5.57). Given continued use of short-chain PFAS in consumer products, further research on their effects on liver health is warranted.

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PFOS、PFOA或PFHxS以外的全氟和多氟烷基物质水平与肝癌风险：嵌套病例对照分析。

全氟辛烷磺酸和肝癌风险的流行病学研究产生了相互矛盾的结果，在诊断前全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）和全氟己磺酸（PFHxS）之间没有强烈或明确的关联。我们现在报告了在美国12个前瞻性队列（853例，853例匹配对照）的巢式病例对照研究中对另外9个PFAS的分析。使用多变量调整条件逻辑回归，我们估计了PFAS水平每增加90个百分位和第10个百分位的优势比。全氟庚酸（PFHpA）与肝癌风险呈正相关（OR: 1.78, 95% CI: 1.26-2.52）；其他PFAS未观察到关联。在性别、癌症亚型和血液采集时间上观察到显著的异质性。男性（OR: 3.72, 95% CI: 2.10-6.59）、肝细胞癌（4.53,2.59-7.94）和采血后诊断≤10年的患者（3.17,1.80-5.57）的相关性更强。鉴于短链PFAS在消费品中的持续使用，有必要进一步研究其对肝脏健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JNCI Journal of the National Cancer Institute 医学-肿瘤学

CiteScore

17.00

自引率

2.90%

发文量

203

审稿时长

4-8 weeks

期刊介绍： The Journal of the National Cancer Institute is a reputable publication that undergoes a peer-review process. It is available in both print (ISSN: 0027-8874) and online (ISSN: 1460-2105) formats, with 12 issues released annually. The journal's primary aim is to disseminate innovative and important discoveries in the field of cancer research, with specific emphasis on clinical, epidemiologic, behavioral, and health outcomes studies. Authors are encouraged to submit reviews, minireviews, and commentaries. The journal ensures that submitted manuscripts undergo a rigorous and expedited review to publish scientifically and medically significant findings in a timely manner.