[Corrigendum] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex.

IF 7.3 3区 医学 Q1 ONCOLOGY
International journal of oncology Pub Date : 2026-11-01 Epub Date: 2026-09-18 DOI:10.3892/ijo.2026.5938
Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter, Christian D Muller, Ali Hamiche, Yves Mély, Christian Bronner, Marc Mousli
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引用次数: 0

Abstract

Following the publication of the above article, and an Expression of Concern statement (doi: 10.3892/ijo.2026.5908) that was published in light of the fact that the GAPDH control western blots shown in Fig. 5A on p. 9 were strikingly similar to the GAPDH control western blots shown in Fig. 5D, the authors have responded to the queries raised by the Editorial Office. The GAPDH panels shown in Figs. 5A and 5D were generated from the same experiment and the same set of protein lysates: Fig. 5A presented the analysis of total protein expression, whereas Fig. 5D presented immunoprecipitation analyses performed using material derived from these same experimental samples. Consequently, the GAPDH loading control was legitimately shared between the two figures. However, given that the original figure legend did not explicitly state that the same GAPDH loading control was used for both analyses, to eliminate any possible ambiguity for readers, the authors have revised Fig. 5 by replacing the representative '-MG132 panel' in Fig. 5A with results obtained from an independent repeat experiment performed under identical experimental conditions. The revised version of Fig. 5 is shown on the next page. Note that this revised figure reproduces the original findings, and does not affect the quantitative analyses, the interpretation of the data, or the conclusions of the study. Regarding a query raised by the Editorial Office concerning the presentation of flow cytometric plots in Fig. 8, the authors explained that Fig. 8E was generated by applying an additional fluorescence gate to the parent flow cytometry dataset shown in Fig. 8B, which represents standard flow cytometric analysis, rather than duplication of experimental data, and so this figure was presented correctly, and as intended by the authors. The authors thank the Editor of International Journal of Oncology for granting them the opportunity to publish this corrigendum, and all the authors agree with its publication. [International Journal of Oncology 59: 89, 2021; DOI: 10.3892/ijo.2021.5269].

[勘误]TIP60通过USP7与UHRF1/USP7复合物的解离控制UHRF1的自动泛素化。
鉴于第9页图5A所示的GAPDH控制的western blots与图5D所示的GAPDH控制的western blots惊人地相似,上述文章和关注表达声明(doi: 10.3892/ijo.2026.5908)发表后,作者已经回应了编辑部提出的疑问。图5A和5D所示的GAPDH面板是由同一实验和同一组蛋白裂解物生成的:图5A为总蛋白表达分析,而图5D为使用来自相同实验样品的材料进行的免疫沉淀分析。因此,GAPDH加载控制在两个图之间合法地共享。然而,考虑到原始图例中没有明确说明两种分析使用了相同的GAPDH加载对照,为了消除读者可能产生的歧义,作者对图5进行了修改,将图5A中具有代表性的“-MG132面板”替换为在相同实验条件下进行的独立重复实验的结果。图5的修订版见下一页。请注意,这一修订后的数据再现了最初的研究结果,并不影响定量分析、数据解释或研究结论。对于编辑部提出的关于图8中流式细胞术图呈现的问题,作者解释说,图8E是在图8B所示的母流式细胞术数据集上添加了一个荧光门生成的,它代表的是标准的流式细胞术分析,而不是重复的实验数据,因此该图呈现正确,并且符合作者的意图。作者感谢《国际肿瘤学杂志》编辑给予他们发表此更正的机会,所有作者都同意其发表。[国际肿瘤学杂志59:89,2021;DOI: 10.3892 / ijo.2021.5269]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.60
自引率
0.00%
发文量
157
审稿时长
2.1 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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