{"title":"Tracking the Fall in Prothrombin Time in Dogs With Anticoagulant Rodenticide Toxicosis Following an Intravenous Dose of Mixed Micelle Phytomenadione","authors":"Erin T. Mooney, Lisa Smart","doi":"10.1111/vec.70155","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Anticoagulant rodenticide toxicosis causes distruption to vitamin K metabolism, leading to excessive bleeding. Mixed micelle phytomenadione (MMP), administered intravenously, is used to reverse the anticoagulant effects of the rodenticide. In dogs with anticoagulant rodenticide toxicosis, prothrombin time (PT) is measured before and after treatment with MMP to assess whether and when normalization of PT has occurred.</p>\n </section>\n \n <section>\n \n <h3> Key Findings</h3>\n \n <p>Eleven patients were enrolled, and one dog twice, resulting in 12 patient events. In two cases, PT normalized within 30 min of administration of MMP, seven within 1 h, and one within 2 h; however, apparent adverse reactions were seen.</p>\n </section>\n \n <section>\n \n <h3> Significance</h3>\n \n <p>Although adverse effects have been reported, coagulopathy can be rapidly reversed in dogs with suspected anticoagulant rodenticide toxicosis with use of intravenous MMP.</p>\n </section>\n </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"713-717"},"PeriodicalIF":1.6000,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of veterinary emergency and critical care","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/vec.70155","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/9/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Anticoagulant rodenticide toxicosis causes distruption to vitamin K metabolism, leading to excessive bleeding. Mixed micelle phytomenadione (MMP), administered intravenously, is used to reverse the anticoagulant effects of the rodenticide. In dogs with anticoagulant rodenticide toxicosis, prothrombin time (PT) is measured before and after treatment with MMP to assess whether and when normalization of PT has occurred.
Key Findings
Eleven patients were enrolled, and one dog twice, resulting in 12 patient events. In two cases, PT normalized within 30 min of administration of MMP, seven within 1 h, and one within 2 h; however, apparent adverse reactions were seen.
Significance
Although adverse effects have been reported, coagulopathy can be rapidly reversed in dogs with suspected anticoagulant rodenticide toxicosis with use of intravenous MMP.
期刊介绍：
The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues.
The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.
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