Prevalence and Associated Factors of Sarcopenia in Patients With Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis.

IF 2.3 3区医学 Q1 ORTHOPEDICS

Journal of Foot and Ankle Research Pub Date : 2026-09-01 DOI:10.1002/jfa2.70201

Wang Hui, Yang Yaping, Lv Tan, Mao Zhigang, Dai Xinyi, Peng Yinbo, Wang Jing

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引用次数: 0

Abstract

Objective: To systematically evaluate the prevalence and influencing factors of diabetic foot sarcopenia.

Methods: We systematically searched PubMed, Embase, Scopus, Web of Science, the Cochrane Library, SinoMed, CNKI, Wanfang, and VIP databases from inception until June 10, 2025, for studies reporting the prevalence and/or influencing factors of sarcopenia in patients with diabetic foot. All meta-analyses were performed using R software (version 4.4.2).

Results: A total of 1164 patients with diabetic foot ulcers were included in 7 studies. Meta-analysis showed that the prevalence of diabetic foot sarcopenia was 31% (95% CI: 0.22-0.41). Pooling of data from two studies indicated a significant association between longer diabetes duration and sarcopenia (OR = 3.33, 95% CI: 1.61-6.87, and p < 0.01). The evidence for other factors was insufficient for meta-analysis.

Conclusion: This review confirms a high prevalence of sarcopenia in patients with diabetic foot. Although an association with longer diabetes duration was observed, this is based on limited studies and requires further validation. These findings advocate for the consideration of early sarcopenia screening and preventive strategies within comprehensive diabetic foot care, potentially mitigating muscle loss and improving long-term outcomes.

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糖尿病足溃疡患者肌肉减少症的患病率及相关因素：一项系统综述和荟萃分析。

目的：系统评价糖尿病足肌减少症的发病情况及影响因素。方法：系统检索PubMed、Embase、Scopus、Web of Science、Cochrane Library、SinoMed、CNKI、万方、VIP等数据库，从建库到2025年6月10日，检索有关糖尿病足患者肌肉减少症患病率和/或影响因素的研究。所有meta分析均使用R软件（版本4.4.2）进行。结果：7项研究共纳入1164例糖尿病足溃疡患者。荟萃分析显示，糖尿病足肌减少症的患病率为31% （95% CI: 0.22-0.41）。两项研究的汇总数据显示，较长的糖尿病病程与肌肉减少症之间存在显著关联（OR = 3.33, 95% CI: 1.61-6.87, p）。结论：本综述证实了糖尿病足患者中肌肉减少症的高发率。虽然观察到与糖尿病持续时间较长的相关性，但这是基于有限的研究，需要进一步验证。这些发现提倡在糖尿病足综合护理中考虑早期肌肉减少症筛查和预防策略，可能减轻肌肉损失并改善长期预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Foot and Ankle Research ORTHOPEDICS-

CiteScore

4.50

自引率

10.30%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Foot and Ankle Research, the official journal of the Australian Podiatry Association and The College of Podiatry (UK), is an open access journal that encompasses all aspects of policy, organisation, delivery and clinical practice related to the assessment, diagnosis, prevention and management of foot and ankle disorders. Journal of Foot and Ankle Research covers a wide range of clinical subject areas, including diabetology, paediatrics, sports medicine, gerontology and geriatrics, foot surgery, physical therapy, dermatology, wound management, radiology, biomechanics and bioengineering, orthotics and prosthetics, as well the broad areas of epidemiology, policy, organisation and delivery of services related to foot and ankle care. The journal encourages submissions from all health professionals who manage lower limb conditions, including podiatrists, nurses, physical therapists and physiotherapists, orthopaedists, manual therapists, medical specialists and general medical practitioners, as well as health service researchers concerned with foot and ankle care. The Australian Podiatry Association and the College of Podiatry (UK) have reserve funds to cover the article-processing charge for manuscripts submitted by its members. Society members can email the appropriate contact at Australian Podiatry Association or The College of Podiatry to obtain the corresponding code to enter on submission.