Enzyme evolution and metabolic engineering for 5-aminolevulinic acid production.

IF 16.6 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2026-09-15 DOI:10.1016/j.tibtech.2026.08.015

Sefli Sri Wahyu Effendi, Yu-Chieh Lin, I-Son Ng

引用次数: 0

Abstract

5-Aminolevulinic acid (5-ALA), a nonproteinogenic amino acid, has emerged as a versatile metabolite for applications in health, agriculture, and sustainability. Advances in ALA synthase engineering and metabolic rewiring have enabled scalable biosynthesis. The next frontier should expand beyond production, positioning it as a gateway to future biotechnological applications.

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5-氨基乙酰丙酸生产的酶进化和代谢工程。

5-氨基乙酰丙酸（5-ALA）是一种非蛋白质原性氨基酸，已成为一种用途广泛的代谢物，在健康、农业和可持续发展等领域得到广泛应用。ALA合成酶工程和代谢重组的进展使可扩展的生物合成成为可能。下一个前沿应该扩展到生产之外，将其定位为未来生物技术应用的门户。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).