CLN8 recycles glycerol backbones for BMP

IF 22.7 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2026-09-15 DOI:10.1038/s41556-026-02069-6

Zhengyue Cao, Cunqi Ye

引用次数: 0

Abstract

Two studies identify CLN8 as a glycerophosphoglycerol acyltransferase that generates the lysophosphatidylglycerol precursor for CLN5-mediated bis(monoacylglycero)phosphate (BMP) biosynthesis. These findings define a key upstream step in BMP synthesis and raise fundamental questions about lipid recycling and metabolic feedback.

查看原文本刊更多论文

CLN8循环甘油骨架形成BMP。

两项研究证实CLN8是一种甘油磷酸酰基转移酶，可产生溶血磷脂酰甘油前体，用于cln5介导的单酰基甘油磷酸（BMP）生物合成。这些发现定义了BMP合成的关键上游步骤，并提出了关于脂质循环和代谢反馈的基本问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology