The efficacy and safety of microwave ablation in benign large thyroid nodules (≥4 cm).

IF 4.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

European Thyroid Journal Pub Date : 2026-10-01 DOI:10.1530/ETJ-26-0013

Hongye Gu, Chaonan Li, Yunhao Luo, Yunjun Liu, Chao Feng, Zhe Song, Jun Luo

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引用次数: 0

Abstract

Objective: The objective of this study was to evaluate the safety and efficacy of ultrasound-guided single-session microwave ablation for benign thyroid nodules >4 cm by comparing outcomes with smaller nodules (<4 cm).

Methods: This retrospective single-center study (2016-2023) analyzed 1,107 patients with 1,463 pathologically confirmed benign thyroid nodules stratified by maximum diameter into four groups: ≤20, 20-40, 40-60, and ≥60 mm. Standardized follow-up was performed at 1, 3, 6, 12, and 24 months post-microwave ablation and then annually. Volume reduction ratio, maximum diameter reduction ratio, recurrence rate, and complications were assessed.

Results: The cohort (127 males and 980 females) had a mean age of 45.8 ± 12.7 years and a mean maximum nodule diameter of 28.9 ± 14.6 mm. Complication rates significantly increased with nodule size (2.59, 5.55, 13.36, and 16.67%, respectively; P < 0.001). Technical efficacy exceeded 90% across all groups (P > 0.05). Volume reduction ratio improved significantly over time across all groups, with statistical differences at 1, 6, 12, and ≥24 months (all P < 0.001) but not at 3 months (P = 0.085). The ≤20 mm group achieved the highest volume reduction ratio at ≥24 months (96% ± 14%).

Conclusion: Ultrasound-guided single-session microwave ablation is safe and effective for large benign thyroid nodules, providing significant volume reduction with acceptable complication profiles while reducing treatment burden.

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微波消融治疗良性甲状腺大结节（≥4cm）的疗效和安全性。

目的：通过比较超声引导下单次微波消融治疗bb0 ~ 4cm良性甲状腺结节与较小结节的疗效，评价超声引导下单次微波消融治疗bb0 ~ 4cm良性甲状腺结节的安全性和有效性。方法：本回顾性单中心研究（2016-2023）对1107例病理确诊的良性甲状腺结节进行分析，按最大直径分为≤20mm、20 ~ 40mm、40 ~ 60mm和≥60mm四组。在微波消融后1、3、6、12和24个月进行标准化随访，然后每年进行一次。评估体积缩小率、最大直径缩小率、复发率和并发症。结果：该队列（男性127例，女性980例）平均年龄45.8±12.7岁，平均最大结节直径28.9±14.6 mm。随着结节大小的增加，并发症发生率显著增加（分别为2.59%、5.55%、13.36%和16.67%,P < 0.001）。各组技术疗效均超过90% （P < 0.05）。体积缩小率随时间的推移在所有组中均有显著改善，在1、6、12和≥24个月时具有统计学差异（P < 0.001），但在3个月时无统计学差异（P = 0.085）。≤20 mm组在≥24个月时体积缩小率最高（96%±14%）。结论：超声引导下单次微波消融治疗甲状腺大良性结节安全有效，体积明显缩小，并发症可接受，治疗负担减轻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Thyroid Journal Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.70

自引率

2.10%

发文量

156

期刊介绍： The ''European Thyroid Journal'' publishes papers reporting original research in basic, translational and clinical thyroidology. Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.