Accelerated biological ageing is associated with a large drusen burden.

IF 3 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2026-09-14 DOI:10.1111/aos.70237

Marie Ørskov, Lasse J Cehofski, Carsten Faber, Paolo Forte, Michael S Hansen, Danson V Muttuvelu, Siar Niazi, Marianne G Schou, Noreddin Shekho, Gregor S Reiter, Tor P Utheim, Anna S Vergmann, Yousif Subhi

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引用次数: 0

Abstract

Purpose: To investigate the association between accelerated biological ageing, measured by Phenotypic Age (PhenoAge) and PhenoAge Acceleration (PhenoAgeAccel), and features of early and intermediate age-related macular degeneration (AMD) in a population-based cohort.

Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey. Biological age was estimated using the PhenoAge algorithm, a composite of routine blood biomarkers and chronological age, and PhenoAgeAccel was defined as the residual from regression of PhenoAge on chronological age. Retinal outcomes were drusen ≥500 μm (primary outcome), drusen ≥125 μm and pigmentary abnormalities. Associations were evaluated using logistic regression adjusted for biological sex, race/ethnicity, smoking, body mass index and diabetes.

Results: A total of 5322 participants were included (mean age 59.4 ± 12.4 years; 50.4% female). Drusen ≥500 μm were present in 4.1%, drusen ≥125 μm in 10.2% and pigmentary abnormalities in 5.6%. PhenoAgeAccel > + 3 years was associated with higher odds of drusen ≥500 μm (OR: 1.56, 95%CI: 1.07-2.27, p = 0.022), whereas no association was observed for <-3 years. Each 1-year increase in PhenoAgeAccel was associated with higher odds of drusen ≥500 μm (OR: 1.02, 95%CI: 1.00-1.04, p = 0.022). PhenoAgeAccel > + 3 years was also associated with drusen ≥125 μm (OR: 1.29, 95%CI: 1.00-1.65, p = 0.049), but not with pigmentary abnormalities.

Conclusion: Accelerated biological ageing was associated with increased drusen burden, but not pigmentary abnormalities, suggesting that early structural features of AMD may reflect broader systemic ageing processes.

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加速的生物老化与巨大的疾病负担有关。

目的：研究以人群为基础的队列中，通过表型年龄（PhenoAge）和表型年龄加速（PhenoAgeAccel）测量的加速生物衰老与早期和中期年龄相关性黄斑变性（AMD）特征之间的关系。方法：本横断面研究使用来自国家健康和营养检查调查的数据。使用常规血液生物标志物和实足年龄的复合算法（PhenoAge）估计生物年龄，并将PhenoAge定义为对实足年龄回归的残差。视网膜结局为≥500 μm（主要结局）、≥125 μm和色素异常。使用经生理性别、种族/民族、吸烟、体重指数和糖尿病校正的逻辑回归对相关性进行评估。结果：共纳入5322例受试者（平均年龄59.4±12.4岁，女性50.4%）。Drusen≥500 μm占4.1%，Drusen≥125 μm占10.2%，色素异常占5.6%。PhenoAgeAccel > + 3年与drusen≥500 μm的几率较高相关（OR: 1.56, 95%CI: 1.07-2.27, p = 0.022），而+ 3年与drusen≥125 μm也无关联（OR: 1.29, 95%CI: 1.00-1.65, p = 0.049），但与色素异常无关。结论：加速的生物老化与老年负担增加有关，但与色素异常无关，这表明AMD的早期结构特征可能反映了更广泛的系统性老化过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.