Not All Pancreatic Masses are Cancer: Pancreatic Tuberculosis Masquerading as Malignancy.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY
ACG Case Reports Journal Pub Date : 2026-09-15 eCollection Date: 2026-09-01 DOI:10.14309/crj.0000000000002300
Ronald Blanco Montecino, Alvaro Cadillo Arbaiza, James Cutrell, Puneet Bajaj, Patricio Polanco, Anna Tavakkoli
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引用次数: 0

Abstract

Pancreatic tuberculosis (TB) is a rare extrapulmonary manifestation that can mimic pancreatic cancer. We report a 61-year-old man presenting with epigastric discomfort, weight loss, elevated liver enzymes, elevated carbohydrate antigen 19-9, and a pancreatic mass causing biliary obstruction. Endoscopic ultrasound-guided biopsies revealed granulomatous inflammation and necrosis. Autoimmune and fungal etiologies were excluded, and acid-fast stains were negative. Definitive diagnosis was achieved through 16S ribosomal RNA sequencing followed by detection of the Mycobacterium tuberculosis hsp65 gene. This case highlights the diagnostic challenge of pancreatic TB and the importance of reconsidering the differential diagnosis when histopathological findings do not align with clinical suspicion.

并非所有胰腺肿块都是癌症:伪装成恶性肿瘤的胰腺结核。
摘要胰脏结核是一种罕见的肺外表现,与胰脏癌相似。我们报告一位61岁男性患者,表现为上腹不适,体重减轻,肝酶升高,碳水化合物抗原19-9升高,胰腺肿块引起胆道梗阻。内镜下超声引导活检显示肉芽肿性炎症和坏死。排除自身免疫和真菌病因,抗酸染色阴性。通过16S核糖体RNA测序和结核分枝杆菌hsp65基因检测获得明确诊断。本病例强调了胰腺结核的诊断挑战,以及当组织病理学发现与临床怀疑不一致时重新考虑鉴别诊断的重要性。
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来源期刊
ACG Case Reports Journal
ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-
自引率
14.30%
发文量
170
审稿时长
12 weeks
期刊介绍: ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.
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