{"title":"Human Peripheral B Cell Subsets","authors":"Shiv Pillai, Elif Çakan, Anson Hui","doi":"10.1111/imr.70177","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>This review will focus on some aspects of the biology of human peripheral B cells and how this biology might inform us as to why these cells are important therapeutic targets. Transitional B cells and the alterations in metabolism in transitional B cells as they mature may be relevant to the induction of B cell tolerance. The human extrafollicular B cell response and the activated B cell subsets that emerge both in extrafollicular responses as well as in germinal center responses will be discussed. The relatively transient nature of activated B cells in contrast to durable memory B cells will be considered and the review will also discuss how durable responses are generated both by extrafollicular responses as well as by germinal center responses.</p>\n </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"342 1","pages":""},"PeriodicalIF":10.6000,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunological Reviews","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/imr.70177","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This review will focus on some aspects of the biology of human peripheral B cells and how this biology might inform us as to why these cells are important therapeutic targets. Transitional B cells and the alterations in metabolism in transitional B cells as they mature may be relevant to the induction of B cell tolerance. The human extrafollicular B cell response and the activated B cell subsets that emerge both in extrafollicular responses as well as in germinal center responses will be discussed. The relatively transient nature of activated B cells in contrast to durable memory B cells will be considered and the review will also discuss how durable responses are generated both by extrafollicular responses as well as by germinal center responses.
期刊介绍：
Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system.
The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
