Hydroxyapatite-yttria stabilized zirconia composite with tannic acid for dental applications: assessment of biological properties

IF 2.6 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS

Journal of the Australian Ceramic Society Pub Date : 2026-03-30 DOI:10.1007/s41779-026-01349-6

Nusrat Yeasmin, Joel Pilli, Shimaa Mehanna, Ujjayan Majumdar, Arjak Bhattacharjee

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Abstract

The development of advanced biomaterials for dental restoration has gained significant attention due to the need for durable and bioactive implant materials. Biofilm formation after implantation remains a major clinical challenge. This study explores tannic acid-loaded hydroxyapatite-yttria-stabilized zirconia as a novel composite for dental applications. Hydroxyapatite (HA) offers excellent biocompatibility, YSZ provides stability in the biological medium, and tannic acid (TA), a natural polyphenol, introduces antimicrobial functionality to help prevent infection. Structural, mechanical, and biological characteristics of the fabricated scaffolds were analyzed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and in vitro biological studies. The analyses confirmed the successful fabrication of TA-loaded HA–YSZ scaffolds. Antibacterial studies showed a significant reduction (~ 99%) in Staphylococcus aureus (S. aureus) growth due to TA incorporation. Cytocompatibility tests confirmed that the material is non-toxic. Bioactivity evaluation in simulated body fluid (SBF) demonstrated an appropriate balance between bioactivity and bio inertness. Overall, the TA-modified HA–YSZ system shows strong potential as a multifunctional material for dental implant applications.

Graphical Abstract

Graphical abstract showing the summary of our work

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含单宁酸的羟基磷灰石-钇稳定氧化锆复合材料的牙科应用：生物特性的评估

由于需要耐用和具有生物活性的种植体材料，先进的生物修复材料的发展受到了广泛的关注。植入后生物膜的形成仍然是一个主要的临床挑战。本研究探索了单宁酸负载羟基磷灰石-钇稳定氧化锆作为一种新型牙科复合材料的应用。羟基磷灰石（HA）具有出色的生物相容性，YSZ在生物介质中具有稳定性，单宁酸（TA）是一种天然多酚，具有抗菌功能，有助于预防感染。利用x射线衍射（XRD）、傅里叶变换红外光谱（FTIR）、扫描电镜（SEM）和体外生物学研究分析了所制备支架的结构、力学和生物学特性。分析证实了ta负载HA-YSZ支架的成功制造。抗菌研究表明，由于TA掺入，金黄色葡萄球菌（S. aureus）的生长显著降低（~ 99%）。细胞相容性测试证实该材料无毒。在模拟体液（SBF）中的生物活性评价显示了生物活性和生物惰性之间的适当平衡。总的来说，ta修饰的HA-YSZ系统显示出强大的潜力，作为一种多功能材料的种植牙应用。图形摘要图形摘要显示了我们工作的总结

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来源期刊

Journal of the Australian Ceramic Society Materials Science-Materials Chemistry

CiteScore

3.70

自引率

5.30%

发文量

123

期刊介绍： Publishes high quality research and technical papers in all areas of ceramic and related materials Spans the broad and growing fields of ceramic technology, material science and bioceramics Chronicles new advances in ceramic materials, manufacturing processes and applications Journal of the Australian Ceramic Society since 1965 Professional language editing service is available through our affiliates Nature Research Editing Service and American Journal Experts at the author''s cost and does not guarantee that the manuscript will be reviewed or accepted