[The unbearable versatility of endocrine aging].

Problemy endokrinologii Pub Date : 2026-09-08 DOI:10.14341/probl13774

R K Mikheev, O R Grigoryan, N N Volevodz, R V Rozhivanov, E V Sheremetyeva, E N Andreeva, G A Melnichenko

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Abstract

Ageing is multifactorial, genetically and epigenetically programmed biological process. Nowadays ageing is acknowledged as extremely actual scientifical, social and demographical problem. Despite the evidence of interactions between ageing and accumulation of endocrine disruptions, the last 150 years of variegated searches for potential endocrine "elixir of lon gevity" brought contradictive, mutually exclusive and even discouraging results. Fortunately, the discovery of referent lab oratory intervals of hormonal blood levels among elderly people improved the overall situation. Traditional treatment of endocrine hormonal deficiency with replacement therapy does not lead to rejuvenation but to potential damage. That's why it is more accepted to interpret hormonal changes among elderly people not only as aging but specific adaptation for "successful ageing". The present review contains modern datas about endocrine ageing of thyroid gland, adrenal glands (hy percorticism, adrenopause), pituitary gland (somatopause, hypoprolactinemia), male (andropause) and female (menopause, hyperandrogenism) hypogonadism.

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[难以忍受的内分泌老化的多样性]。

衰老是一个多因素、遗传和表观遗传程序化的生物过程。如今，老龄化被认为是一个极其现实的科学、社会和人口问题。尽管有证据表明衰老和内分泌紊乱积累之间存在相互作用，但过去150年对潜在的内分泌“长生不老药”的各种研究带来了相互矛盾、相互排斥甚至令人沮丧的结果。幸运的是，老年人血液激素水平的实验室间隔的发现改善了整体情况。传统的替代疗法治疗内分泌激素缺乏症不会导致年轻化，反而会造成潜在的损害。这就是为什么老年人的荷尔蒙变化不仅被解释为衰老，而且更被接受为“成功衰老”的特定适应。本文综述了甲状腺、肾上腺（青春期、肾上腺素暂停）、垂体（生长暂停、低泌乳素血症）、男性（雄性暂停）和女性（更年期、雄激素过多）性腺功能减退等内分泌老化的最新研究资料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Problemy endokrinologii

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