{"title":"ATriple Comparative Study for Burn Wound Healing: Standard Treatment vs Quantum-Smart Proteins vs Laser-Activated QSPs Using in silico Simulation.","authors":"Khalid A Alfaifi","doi":"10.2147/CCID.S552824","DOIUrl":null,"url":null,"abstract":"<p><p>Burn injuries remain a major clinical challenge due to delayed healing, infection risk, and fibrosis. This study employed in silico simulations to compare three therapeutic strategies: (1) silver sulfadiazine (standard care), (2) Quantum-Smart Proteins (QSPs) designed using AI and structural modeling, and (3) QSPs combined with Low-Level Laser Therapy (LLLT, 808 nm, 2 J/cm<sup>2</sup>). Simulated outcomes over 21 days included re-epithelialization, fibrosis, angiogenesis, and tissue biomechanics. Results indicated that QSPs improved wound healing compared to standard care, with the QSP+LLLT group showing the most favorable outcomes. These findings are preliminary and computational in nature but highlight QSPs as a promising avenue for regenerative therapeutics that warrants experimental validation. All findings in this study represent computational predictions only and have not been experimentally validated.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"552824"},"PeriodicalIF":2.5000,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571634/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical, Cosmetic and Investigational Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CCID.S552824","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Burn injuries remain a major clinical challenge due to delayed healing, infection risk, and fibrosis. This study employed in silico simulations to compare three therapeutic strategies: (1) silver sulfadiazine (standard care), (2) Quantum-Smart Proteins (QSPs) designed using AI and structural modeling, and (3) QSPs combined with Low-Level Laser Therapy (LLLT, 808 nm, 2 J/cm2). Simulated outcomes over 21 days included re-epithelialization, fibrosis, angiogenesis, and tissue biomechanics. Results indicated that QSPs improved wound healing compared to standard care, with the QSP+LLLT group showing the most favorable outcomes. These findings are preliminary and computational in nature but highlight QSPs as a promising avenue for regenerative therapeutics that warrants experimental validation. All findings in this study represent computational predictions only and have not been experimentally validated.
期刊介绍：
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
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