Designing Single-Molecule Nanofiber Therapeutics for Breast Cancer and Biofilm Suppression

IF 5.9 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2026-09-14 Epub Date: 2026-08-28 DOI:10.1021/acs.biomac.6c00696

Aishwarya Jayakumar, Arjun Velusamy, Karuppuchamy Subbian, Suganthy Natarajan

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Abstract

Breast carcinoma is the most commonly diagnosed cancer and a leading cause of cancer-related death among women globally. Conventional treatments are limited by poor targeting, systemic toxicity, and susceptibility to secondary infections, highlighting the need for localized multifunctional therapeutic systems. This study aimed to develop poly(vinyl alcohol)-loaded madecassoside nanofibers (PVA@MAD) as a localized therapeutic platform for breast cancer treatment. Fabricated nanofibers exhibited spider-web-like architecture, swelling behavior, hydrophilicity, degradation, and sustained drug release (∼95% at 72 h under acidic conditions). PVA@MAD showed cytotoxicity against MDA-MB-231 cells, with an IC₅₀ value of 49.31 ± 0.010 μg/mL, inducing ROS-mediated apoptosis and inhibiting cell migration, indicating antimetastatic potential. In addition, the nanofibers showed antibacterial activity against Staphylococcus aureus and Escherichia coli. Hemocompatibility, brine shrimp, acute, and subacute toxicity studies confirmed excellent biocompatibility. Overall, PVA@MAD nanofibers offer a promising localized therapeutic approach combining anticancer and antibacterial activities for improved breast cancer management.

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查看原文本刊更多论文

设计单分子纳米纤维治疗乳腺癌和生物膜抑制

乳腺癌是最常见的癌症，也是全球女性癌症相关死亡的主要原因。常规治疗由于靶向性差、全身毒性和对继发感染的易感性而受到限制，突出了对局部多功能治疗系统的需求。本研究旨在开发聚乙烯醇负载的马冬苷纳米纤维（PVA@MAD）作为乳腺癌治疗的局部治疗平台。制备的纳米纤维具有类似蜘蛛网的结构、膨胀性、亲水性、可降解性和持续的药物释放（在酸性条件下72小时释放约95%）。PVA@MAD对MDA-MB-231细胞具有细胞毒性，IC50值为49.31±0.010 μg/mL，可诱导ros介导的细胞凋亡，抑制细胞迁移，具有抗转移潜力。此外，纳米纤维对金黄色葡萄球菌和大肠杆菌具有抗菌活性。血液相容性，盐水对虾，急性和亚急性毒性研究证实了良好的生物相容性。总的来说，PVA@MAD纳米纤维提供了一种有前途的局部治疗方法，结合了抗癌和抗菌活性，改善了乳腺癌的管理。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.