Yicheng Huang, Ruixiang Fang, Xu Lian, Xiarong Huang, Zhenxin Lei, Zongzheng Lan, Nuo Xu, Yi Cui
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引用次数: 0
Abstract
Background: Adolescent myopia has risen sharply, yet the role of metabolic dysregulation remains unclear. This cross-sectional study investigated the association between the Metabolic Score for Insulin Resistance (METS-IR) and myopia in adolescents, and tested whether the interaction with obesity reflects biological synergy.
Methods: Cross-sectional analysis of 3946 adolescents aged 12-19 years from NHANES with complementary analysis in an independent clinical cohort of 561 East Chinese adolescents. Myopia was defined as spherical equivalent ≤ -0.5 diopters. Multivariable logistic regression, subgroup analyses, restricted cubic spline analyses, and sensitivity analyses were performed to assess the association, identify effect modifiers, characterize dose-response relationships, and evaluate the interaction.
Results: In NHANES, myopic adolescents had significantly higher METS-IR levels than non-myopes (32.1 vs. 31.3, P = 0.024). After full adjustment, high METS-IR (>31.84) was associated with 17% greater odds of myopia (OR = 1.17, 95% CI: 1.03-1.34), with a linear dose-response relationship and a myopia-specific exploratory reference point of 31.67. The association was significantly stronger in adolescents with obesity (P for interaction = 0.039). Sensitivity analyses using individual METS-IR components and the BMI-independent triglyceride-glucose index confirmed that the amplification of risk by obesity represents a statistical interaction consistent with biological synergy. In the independent cohort, the association remained significant after adjusting for parental myopia (OR = 1.13, 95% CI: 1.02-1.26).
Conclusion: Higher METS-IR is independently associated with increased myopia risk in adolescents, particularly in those with obesity, and highlights METS-IR as a practical metabolic marker for risk stratification that may help guide nutritional and lifestyle interventions.
期刊介绍：
Journal of the Formosan Medical Association (JFMA), published continuously since 1902, is an open access international general medical journal of the Formosan Medical Association based in Taipei, Taiwan. It is indexed in Current Contents/ Clinical Medicine, Medline, ciSearch, CAB Abstracts, Embase, SIIC Data Bases, Research Alert, BIOSIS, Biological Abstracts, Scopus and ScienceDirect.
As a general medical journal, research related to clinical practice and research in all fields of medicine and related disciplines are considered for publication. Article types considered include perspectives, reviews, original papers, case reports, brief communications, correspondence and letters to the editor.
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