Sustained Remission Following Limited Dupilumab Exposure in Refractory Eosinophilic Esophagitis.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2026-09-11 eCollection Date: 2026-09-01 DOI:10.14309/crj.0000000000002314

Dain Raina Kim, Adam Bubelenyi, Milli Gupta

引用次数: 0

Abstract

Eosinophilic esophagitis (EoE) is a type 2 immune-mediated esophageal disorder that can be refractory to standard therapy. We present a case of a 49-year-old woman with asthma, chronic sinusitis, and nasal polyposis diagnosed with EoE refractory to proton pump inhibitors, dietary modification, and swallowed topical corticosteroids. She was treated with dupilumab in 2023 but discontinued it after 3 months due to side effects. Subsequent esophagogastroduodenoscopies demonstrated sustained histologic and endoscopic remission up to October 2025 (26 months later), after which recurrence of disease was confirmed. This case highlights 2-year sustained remission following limited exposure to dupilumab in refractory EoE.

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难治性嗜酸性食管炎有限Dupilumab暴露后持续缓解。

嗜酸性粒细胞性食管炎（EoE）是一种2型免疫介导的食管疾病，标准治疗难以治愈。我们报告一例49岁女性哮喘、慢性鼻窦炎和鼻息肉，诊断为EoE对质子泵抑制剂、饮食调整和吞食局部皮质类固醇都难治。她在2023年接受了杜匹单抗治疗，但由于副作用，3个月后停药。随后的食管胃十二指肠镜检查显示到2025年10月（26个月后）持续的组织学和内镜缓解，之后确认疾病复发。该病例强调了难治性EoE有限暴露于dupilumab后2年持续缓解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.