An Acid‐Base Promoted Three‐Component Hydrolysis Ring‐Opening Tandem Reaction to Access Thioesters

IF 2.3 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2026-08-01 Epub Date: 2026-09-10 DOI:10.1002/ajoc.70519

Sufan Gao, Dan Hu, Xiaonan Guan, Yuanmao Zhang, Lihua Wang, Yulong Li, Chenyi Li

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Abstract

In this study, a transition metal‐free and thiol‐free method for constructing a series of highly functionalized thioesters has been developed, achieving moderate to good yields from benzothiazolium bromides, aroyl chlorides and H₂O in a three‐component reaction, via an acid‐base‐promoted hydrolysis ring‐opening tandem reaction process. The present protocol features available starting materials, operational simplicity, and mild reaction conditions.

A transition metal‐free and thiol‐free method for constructing a series of highly functionalized thioesters has been developed, achieving moderate to good yields from benzothiazolium bromides, aroyl chlorides and H₂O in a three‐component reaction, via acid‐base‐promoted hydrolysis ring‐opening tandem reaction process.

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查看原文本刊更多论文

酸-碱促进三组分水解开环串联反应获得硫酯

在本研究中，开发了一种不含过渡金属和不含硫醇的方法来构建一系列高功能化硫酯，通过酸-碱促进的水解开环串联反应过程，以苯并噻唑溴、芳酰氯和水为原料，在三组分反应中获得了中等到较高的产率。本方法的特点是起始原料可用，操作简单，反应条件温和。在本研究中，开发了一种不含过渡金属和不含硫醇的方法来构建一系列高功能化硫酯，通过酸-碱促进的水解开环串联反应过程，以苯并噻唑溴、芳酰氯和水为原料，在三组分反应中获得了中等到较高的产率。本方法的特点是起始原料可用，操作简单，反应条件温和。本文提出了一种不含过渡金属和不含硫醇的方法，通过酸-碱促进水解开环串联反应，以苯并噻唑溴、芳酰氯和水为原料，在三组分反应中获得了中等到较高的产率。下载：下载高清图片（23KB）下载：下载全尺寸图片

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.