Trends and regional variations of ischemic heart disease and liver cirrhosis-related mortality among American adults (1999-2023)

IF 1.9 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2026-09-01 DOI:10.1016/j.cegh.2026.102469

Farah Yasmin, Abdul Moeed, Muhammad Ahmed Ali Fahim, Muhammad Omar Larik, Ali Abbas Mankani, Muhammad Sohaib Asghar, Salim Surani

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引用次数: 0

Abstract

Problem considered

Liver cirrhosis (LC) is linked to ischemic heart disease (IHD). This study investigates mortality trends due to concurrent LC and IHD using national-level data in the U.S.

Methods

This retrospective, population-based descriptive study utilized the CDC WONDER (Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research) database to retrieve mortality data among adults aged ≥25 years from 1999 to 2023. Crude rates (CRs), age-adjusted mortality rates (AAMRs) per 100,000 population, and annual percentage changes (APCs) with 95% confidence intervals (CIs) were calculated, and data were stratified by year, sex, race, urbanization, and state.

Results

Among 113,089 deaths, AAMRs decreased from 1999 to 2009 (APC: −1.16; 95% CI: −1.97 to −0.60), increased from 2009 to 2018 (APC: 2.71; 95% CI: 1.80 to 3.51), and rose sharply from 2018 to 2021 (APC: 9.72; 95% CI: 7.56 to 11.15). Rates between 2021 and 2023 were stable. (APC: 0.35; 95% CI: −1.95 to 2.93) Males had triple the AAMRs compared to females (3.08 vs 1.01). Non-Hispanic (NH) American Indian/Alaska Natives had the highest AAMRs (4.05), while NH Asian/Pacific Islanders (0.99) had the lowest. AAMRs in the West (2.14) were the highest, followed by the South (2.12), Midwest (1.77), and Northeast (1.66). Nonmetropolitan areas had higher AAMRs than metropolitan ones (1.96 vs 1.84). States in the top 90th percentile of crude mortality rates included West Virginia (CR: 3.89), Rhode Island (CR: 3.63), Oklahoma (CR: 3.29), Texas (CR: 3.01), and Vermont (CR: 3.01).

Conclusion

Mortality due to concurrent LC and IHD has risen in recent years, remaining higher in men, NH American Indian/Alaska Natives, nonmetropolitan areas, and the West, underscoring the need for strategic interventions to mitigate these disparities.

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美国成年人缺血性心脏病和肝硬化相关死亡率的趋势和地区差异（1999-2023）

肝硬化（LC）与缺血性心脏病（IHD）有关。方法：这项回顾性、基于人群的描述性研究利用疾病控制与预防中心（CDC）的WONDER（疾病控制与预防中心流行病学研究广泛在线数据）数据库检索1999年至2023年年龄≥25岁成年人的死亡率数据。计算每10万人的粗死亡率（CRs）、年龄调整死亡率（AAMRs）和95%置信区间（CIs）的年百分比变化（APCs），并按年份、性别、种族、城市化和州对数据进行分层。结果在113,089例死亡病例中，1999 - 2009年aamr下降（APC: - 1.16, 95% CI: - 1.97 ~ - 0.60）， 2009 - 2018年上升（APC: 2.71, 95% CI: 1.80 ~ 3.51）， 2018 - 2021年急剧上升（APC: 9.72, 95% CI: 7.56 ~ 11.15）。2021年至2023年期间的比率保持稳定。（APC: 0.35; 95% CI: - 1.95 ~ 2.93）男性的aamr是女性的三倍（3.08 vs 1.01）。非西班牙裔（NH）美洲印第安人/阿拉斯加原住民的AAMRs最高（4.05），而NH亚洲/太平洋岛民的AAMRs最低（0.99）。aamr最高的地区是西部（2.14），其次是南部（2.12）、中西部（1.77）、东北部（1.66）。非都市地区的aamr高于都市地区（1.96比1.84）。粗死亡率前90百分位的州包括西弗吉尼亚州（CR: 3.89）、罗德岛州（CR: 3.63）、俄克拉荷马州（CR: 3.29）、德克萨斯州（CR: 3.01）和佛蒙特州（CR: 3.01）。结论：近年来，LC和IHD并发的死亡率有所上升，在男性、NH美洲印第安人/阿拉斯加原住民、非大都市地区和西部地区仍然较高，强调需要采取战略性干预措施来缓解这些差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.