Mapping global research on environmental enteric dysfunction: A bibliometric study of trends and emerging themes

IF 1.9 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2026-09-01 DOI:10.1016/j.cegh.2026.102471

Eri Wijaya, Ansariadi, Veni Hadju, Rizalinda Sjahril, Asri C. Adisasmita, Anwar Mallongi, Suparmi, Esti Nugraheny

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引用次数: 0

Abstract

Problem considered

Environmental enteric dysfunction (EED) is a subclinical inflammatory disorder of the small intestine that results in nutrient malabsorption, stunting, impaired cognitive development, and adverse pregnancy outcomes. It disproportionately affects populations in low- and middle-income countries, where chronic exposure to enteric pathogens and poor sanitation is common. Despite growing recognition as a global health concern, EED remains poorly defined, with no standardized diagnostic tools. This bibliometric analysis examines research trends, leading contributors, and emerging themes to inform future research directions.

Methods

The study analyzed publications related to EED retrieved from the Scopus database, covering the period 1972 to 2024. Data cleaning was performed using OpenRefine. Keyword co-occurrence network analysis was conducted using VOSviewer, while trend and collaboration analyses were carried out in R Studio, and geographic visualization in Tableau.

Results

From 1972 to 2024, 484 publications on EED were identified, with an annual growth rate of 5.06%. Output increased markedly after 2010, driven by growing recognition of EED in child growth and malnutrition. The United States and the United Kingdom led publication output, while Bangladesh, Pakistan, and India were the most active LMICs, though their contributions remain low relative to disease burden. Research focus has shifted from basic pathology to multidisciplinary areas, including microbiota, biomarkers, and WASH-related determinants.

Conclusion

EED research has expanded over five decades, evolving from a focus on malnutrition to biomarkers and mechanistic studies. However, geographic imbalances persist, underscoring the need to strengthen research capacity, promote equitable collaborations, and translate mechanistic insights into scalable, context-appropriate interventions.

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绘制环境肠功能障碍的全球研究：趋势和新主题的文献计量学研究

环境性肠功能障碍（EED）是小肠的一种亚临床炎症性疾病，可导致营养吸收不良、发育迟缓、认知发育受损和不良妊娠结局。它对低收入和中等收入国家人口的影响尤为严重，在这些国家，长期接触肠道病原体和卫生条件差是很常见的。尽管越来越多的人认识到急症是全球健康问题，但急症仍然定义不清，没有标准化的诊断工具。这个文献计量分析考察了研究趋势、主要贡献者和新兴主题，以告知未来的研究方向。方法分析从Scopus数据库检索的1972 ~ 2024年期间与EED相关的出版物。使用OpenRefine进行数据清理。关键词共现网络分析使用VOSviewer，趋势分析和协同分析使用R Studio，地理可视化使用Tableau。结果1972 - 2024年共鉴定出EED类出版物484篇，年增长率为5.06%。2010年后，由于人们越来越认识到EED对儿童生长和营养不良的影响，产量显著增加。美国和英国的出版物产出领先，而孟加拉国、巴基斯坦和印度是最活跃的中低收入国家，尽管相对于疾病负担而言，它们的贡献仍然很低。研究重点已从基础病理学转向多学科领域，包括微生物群、生物标志物和wash相关决定因素。eed研究已经扩展了50多年，从关注营养不良发展到生物标志物和机制研究。然而，地域不平衡仍然存在，强调需要加强研究能力，促进公平合作，并将机制见解转化为可扩展的、适合具体情况的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.