Conjunctival biopsy findings associated with fibrosis and sequelae in ocular Mucous membrane pemphigoid.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2026-09-11 DOI:10.1007/s10792-026-04273-7

Ariana Ringer, Andrea Smichowski, Carlos Nuncio Siegrist, German Daniel Grossi, Ramiro Adrian Gómez, Jorge Oscar Zarate, Javier Eduardo Rosa, Maria Lorena Brance, Ana Rosa Pérez, Ignacio Javier Gandino

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引用次数: 0

Abstract

Purpose: Ocular mucous membrane pemphigoid (OcMMP) leads to fibrosis of the conjunctiva with potential sequelae. Our objective was to describe biopsies from patients with OcMMP and identify biopsy characteristics associated with fibrosis and sequelae.

Methods: Patients with histologically confirmed OcMMP were selected. Fibrosis grades were defined according to Foster's stages. The subjects were divided into two groups: early stages (0 and 1) versus later stages (2, 3, and 4). A Cox multivariate analysis was performed to determine whether immunofluorescence deposits were associated with sequelae.

Results: Fifty-seven patients were included. The mean age at diagnosis was 62.7 (SD 13.2) years, and 41 (71.9%) were women. The follow-up time was 1.5 years (IQR 0.3-3). Patients with early Foster were 50.9%. The presence of mast cells was associated with early stages, whereas eosinophils were associated with later stages at the time of diagnosis. In the multivariate Cox regression analysis, the presence of IgA deposits was associated with developing sequelae (HR 10.8; IC 95% 1.3-92.9; p 0.03).

Conclusion: Eosinophils were more frequently observed in patients with advanced Foster stages, and IgA was associated with the sequelae.

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结膜活检结果与眼粘膜类天疱疮的纤维化和后遗症有关。

目的：眼粘膜类天疱疮（OcMMP）可导致结膜纤维化并有潜在的后遗症。我们的目的是描述OcMMP患者的活检，并确定与纤维化和后遗症相关的活检特征。方法：选择组织学证实的OcMMP患者。纤维化分级根据福斯特氏分期确定。受试者被分为两组：早期阶段（0和1）和后期阶段（2、3和4）。进行Cox多变量分析以确定免疫荧光沉积是否与后遗症有关。结果：纳入57例患者。诊断时平均年龄为62.7岁（SD 13.2），女性41例（71.9%）。随访时间1.5年（IQR 0.3-3）。早期福斯特患者占50.9%。肥大细胞的存在与早期阶段有关，而嗜酸性粒细胞在诊断时与晚期阶段有关。在多变量Cox回归分析中，IgA沉积的存在与发展中的后遗症相关（HR 10.8; IC 95% 1.3-92.9; p 0.03）。结论：嗜酸性粒细胞在福斯特晚期患者中更为常见，IgA与后遗症有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.