The Overlapping Symptoms of Perimenopause and Opioid Withdrawal: When Hormone Therapy is "Even more Important for My Recovery than My Methadone".

IF 3.1 3区医学 Q1 SUBSTANCE ABUSE

Journal of Addiction Medicine Pub Date : 2026-09-11 DOI:10.1097/ADM.0000000000001765

McKenna Klausner, Daniel Roche, Katrina Mark

引用次数: 0

Abstract

Hot flushes, or vasomotor symptoms in menopause, are prevalent in both menopause and opioid withdrawal. While our understanding is limited, the physiology and mechanisms behind vasomotor symptoms in menopause and opioid withdrawal hot flushes are likely similar. Both types of hot flushes are associated with an increase in norepinephrine production and dysregulation of β-endorphin levels. In this case, we present the case of a 46-year-old perimenopausal female who misattributed menopausal hot flushes to opioid withdrawal. She initiated methadone; however, her symptoms of hot flushes did not improve. After being referred to a gynecologist, she started hormone therapy, which completely resolved her symptoms. We discuss the potential implications for clinical care given the overlapping physiologic pathways that lead to symptoms of menopause and opioid withdrawal.

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围绝经期和阿片类药物戒断的重叠症状：当激素治疗“对我的康复比美沙酮更重要”时。

更年期的潮热或血管舒缩症状在更年期和阿片类药物戒断中都很普遍。虽然我们的理解是有限的，但更年期血管舒缩症状和阿片类药物戒断性潮热背后的生理和机制可能是相似的。两种类型的潮热都与去甲肾上腺素分泌增加和β-内啡肽水平失调有关。在这种情况下，我们提出的情况下，一个46岁的围绝经期女性谁错误地归因于更年期潮热阿片类药物戒断。她开始使用美沙酮；然而，她的潮热症状并没有改善。在被介绍给妇科医生后，她开始了激素治疗，这完全解决了她的症状。我们讨论了临床护理的潜在意义给予重叠的生理途径，导致更年期和阿片类药物戒断症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Addiction Medicine 医学-药物滥用

CiteScore

6.10

自引率

9.10%

发文量

260

审稿时长

>12 weeks

期刊介绍： The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.