Fabrication and In Vitro Biocompatibility of Hydroxyapatite/Titania@Calcium Titanate Hydroxide Nanosheet Microspheres

IF 2.6 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS

International Journal of Applied Ceramic Technology Pub Date : 2026-09-08 DOI:10.1111/ijac.70270

Rui Hou, Jing Zhang, Song Chen, Like Cao, Meiwen An, Weiyi Chen

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Abstract

The surface structure of biomaterials is one of the important factors influencing cell adhesion and proliferation. In this study, the novel hierarchical hydroxyapatite (HAp)/titania/calcium titanate hydroxide nanosheet microspheres were synthesized by in situ growth of calcium titanate hydroxide nanosheets on the HAp/titania microspheres after hydrothermal treatment in sodium hydroxide solution. Their microstructure and in vitro biocompatibility were investigated. SEM observations showed that each microsphere was spherical in morphology and had diameters of 50–200 µm. The surface of each microsphere was constructed of numerous nanosheets with diameters of 10–30 nm and exhibited hierarchical structure. XRD pattern showed that those nanosheets were assigned to calcium titanate hydroxide. TEM observations showed that Ca, O, and Ti elements were well distributed in each nanosheet. In vitro biocompatibility evaluation showed that the hierarchical HAp/titania/calcium titanate hydroxide nanosheet microspheres were biocompatible and enhanced cell adhesion and proliferation in contrast with nanosheet-free HAp/titania microspheres, indicating that they have potential as novel biocompatible cell carriers.

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羟基磷灰石/Titania@Calcium羟基钛酸盐纳米微球的制备及体外生物相容性研究

生物材料的表面结构是影响细胞粘附和增殖的重要因素之一。在氢氧化钠溶液中，通过水热处理羟基磷灰石/二氧化钛/氢氧化钛钙纳米片在羟基磷灰石/二氧化钛微球上原位生长，合成了新型的羟基磷灰石/二氧化钛/氢氧化钛钙纳米片微球。研究了它们的微观结构和体外生物相容性。SEM观察表明，每个微球形貌为球形，直径为50 ~ 200µm。每个微球的表面由许多直径为10-30 nm的纳米片构成，并呈现层次结构。XRD图谱表明，这些纳米片被分配到羟基钛酸钙上。透射电镜观察表明，Ca、O和Ti元素在各纳米片上分布均匀。体外生物相容性评价表明，层次化羟基磷灰石/二氧化钛/氢氧化钙纳米片微球具有生物相容性，与无纳米片的羟基磷灰石/二氧化钛微球相比，具有增强细胞粘附和增殖的能力，具有作为新型生物相容性细胞载体的潜力。

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来源期刊

International Journal of Applied Ceramic Technology 工程技术-材料科学：硅酸盐

CiteScore

3.90

自引率

9.50%

发文量

280

审稿时长

4.5 months

期刊介绍： The International Journal of Applied Ceramic Technology publishes cutting edge applied research and development work focused on commercialization of engineered ceramics, products and processes. The publication also explores the barriers to commercialization, design and testing, environmental health issues, international standardization activities, databases, and cost models. Designed to get high quality information to end-users quickly, the peer process is led by an editorial board of experts from industry, government, and universities. Each issue focuses on a high-interest, high-impact topic plus includes a range of papers detailing applications of ceramics. Papers on all aspects of applied ceramics are welcome including those in the following areas: Nanotechnology applications; Ceramic Armor; Ceramic and Technology for Energy Applications (e.g., Fuel Cells, Batteries, Solar, Thermoelectric, and HT Superconductors); Ceramic Matrix Composites; Functional Materials; Thermal and Environmental Barrier Coatings; Bioceramic Applications; Green Manufacturing; Ceramic Processing; Glass Technology; Fiber optics; Ceramics in Environmental Applications; Ceramics in Electronic, Photonic and Magnetic Applications;