Photoaccelerated aza-Michael addition of pyrazoles to α, β-unsaturated carbonyl compounds

IF 2 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2026-08-03 Epub Date: 2026-08-13 DOI:10.1080/00397911.2026.2711086

Yanhui Zhao (Data curation Methodology Validation Writing – original draft Writing – review & editing), Xue Zhang (Conceptualization Funding acquisition Methodology Project administration Writing – original draft Writing – review & editing), Mingzhao Li (Data curation Formal analysis Investigation Methodology Writing – original draft), Jiaman Li (Data curation Formal analysis Methodology Writing – original draft), Xinxin Liu (Data curation Formal analysis Investigation Writing – original draft), Haifeng Yu (Conceptualization Funding acquisition Writing – original draft Writing – review & editing)

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引用次数: 0

Abstract

N-Alkylpyrazoles are an important subclass of pyrazoles due to their good physiological and pharmacological activities. Here, we report photoaccelerated aza-Michael addition of pyrazoles to α, β-unsaturated carbonyl compounds to provide N-alkylpyrazoles. The advantages, including mild conditions, broad scope, ease of scale-up, high atom-economy, avoiding the use of metals, bases, photocatalysts and additives, make the reaction useful and practical.

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吡唑与α， β-不饱和羰基化合物的光加速aza-Michael加成反应

n -烷基吡唑具有良好的生理药理活性，是吡唑类中一个重要的亚类。在这里，我们报道了光加速aza-Michael加成吡唑到α， β-不饱和羰基化合物得到n -烷基吡唑。该反应具有条件温和、反应范围广、易于放大、原子经济性高、避免使用金属、碱、光催化剂和添加剂等优点，具有实用性和实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.