Caffeine stimulates in vivo overall cell metabolism. Microcalorimetric measurement of heat production in human platelets.

Abstract

The influence of caffeine on overall cell metabolism was studied in human platelets by measurement of cell heat production rate. One hour after administration of 100-200 mg of caffeine, corresponding to 1-2 cups of coffee, significantly increased values (p less than 0.001) were found, 12 +/- 7%. A return to normal values was noted 1 hour later. The cell metabolic stimulation is presumably due to increased catecholamines. A temporary significant rise in systolic (p less than 0.02) and diastolic (p less than 0.05) blood pressure was observed 1 hour after ingestion of caffeine.