HIVE MIND - Establishing diagnostic criteria for HIV associated acquired epidermodysplasia verruciformis: an international Delphi study.

Q1 Medicine

Wellcome Open Research Pub Date : 2026-08-29 eCollection Date: 2026-01-01 DOI:10.12688/wellcomeopenres.26218.3

Sophie H Kelly, Stephen L Walker, Nicola Willis, Rashida A Ferrand, L Claire Fuller, Eneyi Kpokiri, Vimbainashe Karimatsenga, Sinéad M Langan

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引用次数: 0

Abstract

Background: Acquired epidermodysplasia verruciformis (aEV) is a skin condition caused by increased vulnerability to cutaneous human papillomaviruses. aEV disproportionately affects people who acquire HIV perinatally. There are no accepted diagnostic criteria for aEV. The lack of routine diagnosis has limited research into this condition. There are no community prevalence estimates, no evidence-based treatments and no cohort studies to understand the risk of skin malignancy. Most people with perinatally-acquired HIV, live in low-resource settings without access to specialist skin doctors or skin biopsies. There is therefore a need to develop diagnostic criteria that can be used by non-specialists and are applicable in low-resource settings.

Aim: This Delphi study aims reach consensus on screening and diagnostic criteria for HIV-associated aEV which are applicable in both high and low resource settings.

Methods: Modified Delphi methodology will be used to achieve expert consensus. A panel of 20-30 experts with at least 5 years' experience in HIV or dermatology and experience with aEV will be asked to complete a series of surveys. Firstly, they will contribute all possible features of aEV. They will then rate these features in terms of importance. This will be used to guide the creation of draft diagnostic criteria. Panellists will rate their agreement with each criterion and adoption of the criteria as a whole. This will continue until consensus is reached. Consensus is defined a priori as when more than >60% of the panel either agree or strongly agree with each criterion and ≥ 80% of the panel with the adoption of criteria as a whole.

Expected outcomes: A screening tool to identify people with possible aEV who warrant further examination.A set of diagnostic criteria that can be applied in real world settings to diagnose aEV.

Ethical approval: This study has been approved by the LSHTM Research Ethics Committee (Reference: 33189.).

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HIVE MIND -建立艾滋病毒相关获得性表皮发育不良的全球相关诊断标准：一项国际德尔菲研究。

背景：获得性疣状表皮发育不良（aEV）是一种皮肤疾病，由皮肤人乳头瘤病毒易感性增加引起。aEV对围产期感染艾滋病毒的人的影响尤为严重。目前还没有公认的aEV诊断标准。常规诊断的缺乏限制了对这种疾病的研究。没有社区患病率估计，没有基于证据的治疗方法，也没有队列研究来了解皮肤恶性肿瘤的风险。大多数围产期获得性艾滋病毒感染者生活在资源匮乏的环境中，无法获得专业皮肤医生或皮肤活检。因此，有必要制定非专业人员可以使用并适用于全球的诊断标准。目的：本德尔菲研究旨在就hiv相关aEV的筛查和诊断标准达成共识，该标准适用于资源丰富和资源匮乏的环境。方法：采用改进的德尔菲法，征求专家意见。一个由20-30名具有至少5年艾滋病毒或皮肤病学经验和aEV经验的专家组成的小组将被要求完成一系列调查。首先，他们将贡献电动汽车的所有可能功能。然后他们将根据重要性对这些特征进行评级。这将用于指导诊断标准草案的创建。小组成员将对他们对每个标准的同意程度和对标准的整体采用程度进行评分。这将继续下去，直到达成共识为止。共识被先验地定义为：超过60%的专家组同意或强烈同意每个标准，并且≥80%的专家组同意整体采用标准。预期结果：一种筛查工具，用于识别可能患有aEV并需要进一步检查的人。一套诊断标准，可在现实环境中用于诊断aEV。伦理批准：本研究已获得LSHTM研究伦理委员会（参考文献：33189）的批准。

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来源期刊

Wellcome Open Research Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

5.50

自引率

0.00%

发文量

426

审稿时长

1 weeks

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