Abdul Shadab, Usama Ahmad, Yahya E. Choonara, Md Faiyazuddin
{"title":"Rewriting the mRNA Delivery Map: Albumin Hitchhiking Lipid Nanoparticles for Safer and Smarter Nanomedicine","authors":"Abdul Shadab, Usama Ahmad, Yahya E. Choonara, Md Faiyazuddin","doi":"10.1021/acsmaterialsau.6c00068","DOIUrl":null,"url":null,"abstract":"<p>LNPs are the basis of mRNA and nucleic acid-based therapeutics.\r\nHowever, their remarkable clinical potential is limited by a persistent\r\nchallenge, i.e., nonspecific accumulation in the liver and associated\r\nhepatotoxicity. Traditional strategies, such as PEGylation and lipid\r\nionization modification, have reached a point of low therapeutic value-add\r\nto control biodistribution. Recently published studies present an\r\ninnovative concept: LNPs that recruit albumin, exploiting interactions\r\nwith endogenous albumin to avoid liver accumulation and simultaneously\r\nimprove delivery through the lymphatic system for immune-modulation.\r\nThis review provides a concise incursion into such strategies that\r\nredefine stealth nanomedicine, not as chemical camouflage but as a\r\nbiological alliance with plasma transport proteins, paving the way\r\nfor a new paradigm of self-protecting nanocarriers for safer and more\r\nprecise mRNA therapeutics.</p>","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"6 5","pages":"956–973"},"PeriodicalIF":9.1000,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Materials Au","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsmaterialsau.6c00068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
LNPs are the basis of mRNA and nucleic acid-based therapeutics.
However, their remarkable clinical potential is limited by a persistent
challenge, i.e., nonspecific accumulation in the liver and associated
hepatotoxicity. Traditional strategies, such as PEGylation and lipid
ionization modification, have reached a point of low therapeutic value-add
to control biodistribution. Recently published studies present an
innovative concept: LNPs that recruit albumin, exploiting interactions
with endogenous albumin to avoid liver accumulation and simultaneously
improve delivery through the lymphatic system for immune-modulation.
This review provides a concise incursion into such strategies that
redefine stealth nanomedicine, not as chemical camouflage but as a
biological alliance with plasma transport proteins, paving the way
for a new paradigm of self-protecting nanocarriers for safer and more
precise mRNA therapeutics.
期刊介绍：
ACS Materials Au is an open access journal publishing letters articles reviews and perspectives describing high-quality research at the forefront of fundamental and applied research and at the interface between materials and other disciplines such as chemistry engineering and biology. Papers that showcase multidisciplinary and innovative materials research addressing global challenges are especially welcome. Areas of interest include but are not limited to:Design synthesis characterization and evaluation of forefront and emerging materialsUnderstanding structure property performance relationships and their underlying mechanismsDevelopment of materials for energy environmental biomedical electronic and catalytic applications
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