Concurrent substitutions H3 S28C or S31C/Y in H3 K27-altered diffuse midline gliomas may represent mutation bias, apart from being a source of potential diagnostic pitfall. Scientific commentary on: “H3K27ME3 loss in diffuse midline gliomas lacking H3K27M or EZHIP expressions, a potential diagnostic pitfall!”

IF 10.3 1区医学 Q1 CLINICAL NEUROLOGY

Acta Neuropathologica Pub Date : 2026-09-11 DOI:10.1007/s00401-026-03083-6

Margarita Zaytseva, Ludmila Papusha, Alexander Druy

引用次数: 0

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H3 k27改变的弥漫性中线胶质瘤中H3 S28C或S31C/Y的同时替换可能代表突变偏倚，除了是潜在诊断缺陷的来源。科学评论：“缺乏H3K27M或EZHIP表达的弥漫性中线胶质瘤中H3K27ME3缺失，一个潜在的诊断缺陷！”

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neuropathologica 医学-病理学

CiteScore

23.70

自引率

3.90%

发文量

118

审稿时长

4-8 weeks

期刊介绍： Acta Neuropathologica publishes top-quality papers on the pathology of neurological diseases and experimental studies on molecular and cellular mechanisms using in vitro and in vivo models, ideally validated by analysis of human tissues. The journal accepts Original Papers, Review Articles, Case Reports, and Scientific Correspondence (Letters). Manuscripts must adhere to ethical standards, including review by appropriate ethics committees for human studies and compliance with principles of laboratory animal care for animal experiments. Failure to comply may result in rejection of the manuscript, and authors are responsible for ensuring accuracy and adherence to these requirements.