Weight Loss and Physical Activity Reduces Perceived Physical Fatigability Among Older Adults With Obesity.

Obesity (Silver Spring, Md.) Pub Date : 2026-09-09 DOI:10.1002/oby.70298

Reagan E Garcia, Jason Fanning, Chaeryon Kang, Bonny Rockette-Wagner, Christopher E Kline, Barbara J Nicklas, Nancy W Glynn

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Abstract

Objective: This study aimed to evaluate the impact of three lifestyle interventions on perceived physical fatigability.

Methods: Concurrent with a dietary weight loss program (caloric deficit ~400 kcal/day, weekly dietitian support), older adults with obesity (N = 183) were randomized to three groups: aerobic exercise (150-200 min/week of moderate-intensity treadmill walking; n = 60), daylong movement (improving daily activity distribution, progressively increase steps/day; n = 63), or combination (aerobic and daylong movement interventions; n = 60). Perceived physical fatigability (Pittsburgh Fatigability Scale [PFS] Physical score, range 0-50, and Rating of Perceived Exertion [RPE] after a 5-min 0% grade treadmill walk, range 6-20; higher = greater fatigability) was measured at baseline, 6 months (post-intensive intervention), and 18 months (end of maintenance period).

Results: Participants (69.6 ± 4.3 years, 77% female, 74% White, 35.6 ± 3.8 kg/m² BMI) had a PFS Physical score 20.6 ± 7.6 and RPE Fatigability 9.6 ± 1.9 at baseline. Clinically relevant improvements were observed in PFS score from baseline to 6 months (-4.4 points, p = 0.002) and were largely maintained at 18 months (-3.0 points, p = 0.03) after adjustment for baseline age, sex, education, intervention group, and time × intervention group (p = 0.83). RPE Fatigability did not improve (p > 0.05).

Conclusions: Multiple physical activity strategies in conjunction with weight loss improved perceived physical fatigability over time among older adults with obesity.

Trial registration: ClinicalTrials.gov identifier: NCT02923674.

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减肥和体育活动可减少老年肥胖患者的身体疲劳。

目的：本研究旨在评估三种生活方式干预对感知身体疲劳的影响。方法：在饮食减肥计划（热量不足~400千卡/天，每周营养师支持）的同时，将肥胖老年人（N = 183）随机分为三组：有氧运动（150-200分钟/周中等强度的跑步机行走，N = 60），全天运动（改善日常活动分布，逐步增加步数/天，N = 63），或组合（有氧和全天运动干预，N = 60）。在基线、6个月（强化干预后）和18个月（维持期结束）测量感知身体疲劳（匹兹堡疲劳量表[PFS]生理评分，范围0-50，以及5分钟0%跑步机步行后的感知运动评分[RPE]，范围6-20；越高=越容易疲劳）。结果：参与者（69.6±4.3岁，女性77%，白人74%，BMI 35.6±3.8 kg/m2）基线时PFS物理评分为20.6±7.6，RPE疲劳评分为9.6±1.9。PFS评分从基线到6个月（-4.4分，p = 0.002）有临床相关的改善，在调整基线年龄、性别、教育程度、干预组和时间×干预组后，PFS评分在18个月时基本保持（-3.0分，p = 0.03）（p = 0.83）。RPE疲劳性无明显改善（p < 0.05）。结论：随着时间的推移，多种体育活动策略与减肥相结合可改善老年肥胖患者的感知身体疲劳。试验注册：ClinicalTrials.gov标识符：NCT02923674。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Obesity (Silver Spring, Md.)

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