Respiratory oscillometry reference values in Polish children and adolescents: a nationwide multicenter cross-sectional study (OSCILLONiCA-PL-Kids) – Study Protocol

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2026-09-01 Epub Date: 2026-09-09 DOI:10.1016/j.advms.2026.09.002

Eliza Wasilewska, Jakub Radliński, Alina Minarowska, Joanna Peradzyńska, Katarzyna Walicka-Serzysko, Katarzyna Krenke, Zbigniew Doniec, Henryk Mazurek, Hanna Dmeńska, Joanna Połomska, Hanna Sikorska-Szaflik, Irena Wojsyk-Banaszak

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引用次数: 0

Abstract

Purpose

The aim of this study was to establish nationwide reference values for respiratory oscillometry parameters (Rrs, Xrs, Fres, and AX) in healthy Polish children and adolescents aged 3–18 years and to develop prediction equations and percentile charts to facilitate the interpretation of oscillometry results in pediatric clinical practice.

Materials and methods

This nationwide multicenter cross-sectional study (OSCILLONiCA-PL-Kids) is being conducted in 12 pediatric centers across Poland. Healthy participants aged 3–18 years are recruited through schools and kindergartens. Standardized operating procedures, centralized data management, and quality control ensure methodological consistency across centers. Anthropometric data, health questionnaires, and oscillometry measurements (Jaeger; Vyaire) are collected according to European Respiratory Society standards. Statistical modeling applies Generalized Additive Models for Location, Scale and Shape (GAMLSS) to derive prediction equations and z-scores. The primary outcome is the development of age- and height-specific reference equations for oscillometric parameters in healthy children. This study is registered at ClinicalTrials.gov (NCT07207720).

Results

Approximately 2500 participants are expected to provide a large multicenter dataset for developing nationwide oscillometry reference equations. Participant recruitment and data collection are ongoing. Final analyses will be performed after completion of data collection and data processing; results will be reported in a separate publication.

Conclusions

The OSCILLONiCA-PL-Kids study represents the first nationwide multicenter initiative to establish oscillometry reference values in the Polish pediatric population. The resulting normative equations and percentile charts will facilitate the standardized interpretation of oscillometry and contribute to improved diagnosis and monitoring of pediatric respiratory diseases.

查看原文本刊更多论文

波兰儿童和青少年的呼吸振荡测量参考值：一项全国性多中心横断面研究(OSCILLONiCA-PL-Kids) -研究方案

目的：本研究的目的是建立波兰3-18岁健康儿童和青少年呼吸振荡测量参数（Rrs、Xrs、Fres和AX）的全国参考值，并建立预测方程和百分位数图，以便在儿科临床实践中解释振荡测量结果。材料和方法：这项全国性的多中心横断面研究（OSCILLONiCA-PL-Kids）正在波兰的12个儿科中心进行。通过学校和幼儿园招募3-18岁的健康参与者。标准化的操作程序、集中的数据管理和质量控制确保了各中心方法的一致性。人体测量数据、健康问卷和振荡测量（Jaeger; Vyaire）是根据欧洲呼吸学会的标准收集的。统计建模应用位置、规模和形状的广义可加模型（GAMLSS）来推导预测方程和z分数。主要结果是建立健康儿童的年龄和身高特异性振荡参数参考方程。该研究已在ClinicalTrials.gov注册（NCT07207720）。结果：大约2500名参与者预计将提供一个大型的多中心数据集，用于开发全国性的振荡测量参考方程。参与者招募和数据收集正在进行中。数据收集和数据处理完成后进行最终分析；结果将在另一份出版物中报告。结论：振荡- pl - kids研究代表了第一个在波兰儿科人群中建立振荡测量参考值的全国性多中心倡议。由此产生的规范方程和百分位数图将有助于对振荡测量法的标准化解释，并有助于改进儿科呼吸系统疾病的诊断和监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.