Oxazole- and isoxazole-containing derivatives of high importance in the development of new drugs: natural sources, biogenesis, molecular targets and domino protocols.
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引用次数: 0
Abstract
Covering: 2015 to 2026The structural diversity of oxazole- and isoxazole-containing natural products includes both linear and macrocyclic structures. These N,O-heterocycles are produced by a range of organisms, e.g. bacteria, fungi, marine sponges, and plants. The synthesis of oxazoles and isoxazoles via cascade synthetic methods can provide natural product mimics. To better understand the role of the oxazole and isoxazole moieties in drug development from the perspective of the molecular mechanism of action, selected binding modes to molecular targets are discussed and their full list is provided. Although isoxazole- and oxazole-containing natural products are biologically attractive, modifications of their scaffolds are required in many cases to release their full biological potential. The bibliography of the review covers mainly works published in the years from 2015 to 2026.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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