Exploring the Anticancer Potential of Schiff Base Complexes: A Mini-Review

IF 3.5 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2026-09-09 DOI:10.1002/cmdc.70484

Atif Ahmad, Anam, Marcos V. Palmeira-Mello, Sabir Khan, José Clayston Melo Pereira

引用次数: 0

Abstract

Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes. These metal-based compounds have attracted significant attention due to their enhanced biological activities, particularly their ability to act toward anticancer chemotherapy. This mini-review provides a comprehensive overview of Schiff base complexes reported over the last 5 years, highlighting the recent advances related to their biological investigations. Cytotoxicity and interactions with biological targets have been detailed. The mechanisms underlying the capacity of these complexes to induce cell death in cancer cells are also described.

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探索希夫碱配合物的抗癌潜力：综述。

希夫碱以其与几种过渡金属形成稳定的配位化合物的能力而闻名，这使得它们在药物化学方面很有价值。这些金属基化合物由于其增强的生物活性，特别是它们在抗癌化疗中的作用而引起了人们的极大关注。本文对近5年来报道的希夫碱配合物进行了综述，重点介绍了其生物学研究的最新进展。细胞毒性和与生物靶点的相互作用已经详细介绍。这些复合物诱导癌细胞死亡的潜在机制也被描述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.