Elevated Non-Fasting Remnant Cholesterol Predicts All-Cause Mortality in Hemodialysis Patients.

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2026-09-08 DOI:10.1002/1744-9987.70217

Xuelei Zhang, Xin Li, Shuoqiang Hu, Dongqi Song, Qiang Ma

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Abstract

Introduction: Remnant cholesterol (RC) has been proposed as a mortality indicator in various populations; however, it remains unknown whether non-fasting RC can predict prognosis in patients undergoing hemodialysis (HD).

Methods: This retrospective study enrolled 203 patients who underwent regular HD between May 2023 and May 2026. Patients were divided into four groups according to quartiles of non-fasting RC.

Results: Cox proportional hazards models revealed that RC was an independent predictor of all-cause mortality (hazard ratio [HR], 2.26; 95% confidence interval [CI], 1.10-4.65). In a joint analysis using upper quartile cut-offs of RC and low-density lipoprotein cholesterol (LDL-C), the high RC/high LDL-C group had a significantly higher mortality risk (HR: 2.67; 95% CI: 1.51-4.72) compared with the reference group. Isolated elevation of either RC or LDL-C was not associated with an increased mortality risk.

Conclusions: RC may be a useful predictor of all-cause mortality in patients undergoing HD.

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血液透析患者非空腹残余胆固醇升高可预测全因死亡率。

残余胆固醇（RC）已被提出作为各种人群的死亡率指标；然而，非空腹RC是否能预测血液透析（HD）患者的预后仍不清楚。方法：这项回顾性研究纳入了2023年5月至2026年5月期间接受常规HD治疗的203例患者。根据非禁食RC的四分位数将患者分为四组。结果：Cox比例风险模型显示，RC是全因死亡率的独立预测因子（风险比[HR]， 2.25； 95%可信区间[CI]， 1.10-4.62）。在一项使用RC和低密度脂蛋白胆固醇（LDL-C）上四分位数截断值的联合分析中，与对照组相比，高RC/高LDL-C组的死亡风险显著更高（HR: 2.67; 95% CI: 1.51-4.76）。单独升高的RC或LDL-C与死亡风险增加无关。结论：RC可能是HD患者全因死亡率的有效预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

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