Systemic inflammatory indices and lung cancer risk by smoking and alcohol use in Korean men: A secondary dataset analysis of the Korean Cancer Prevention Study-II.

IF 2.4 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2026-09-08 eCollection Date: 2026-01-01 DOI:10.18332/tid/226556

Jong Won Shin, Thien Minh Nguyen, Sun Ha Jee

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引用次数: 0

Abstract

Introduction: Systemic inflammation has been implicated in cancer development, but prospective evidence regarding its association with lung cancer risk remains limited. This study evaluated the associations of systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) with lung cancer risk according to smoking status, alcohol drinking status, and their combined exposure patterns in Korean men.

Methods: This secondary dataset analysis utilized data from the Korean Cancer Prevention Study-II (KCPS-II), a nationwide prospective cohort. Among 20167 men, 236 incident lung cancer cases were identified during a median follow-up of approximately 14 years. Adjusted hazard ratios (AHRs) for lung cancer per 1 standard deviation (SD) increase in SII and NLR were estimated using multivariable Cox proportional hazards models adjusted for demographic, lifestyle, liver function, and endogenous antioxidant biomarkers. Analyses were performed in the overall population and stratified by smoking and alcohol status, including concurrent current smokers and drinkers.

Results: Higher SII and NLR were associated with increased lung cancer risk in Korean men, with consistent associations observed among current smokers, current drinkers, and individuals with concurrent current smoking and drinking. In combined exposure analyses, substantially elevated risks were observed among current smokers with high inflammatory marker levels (SII: AHR=3.58; 95% CI: 2.51-5.09; NLR: AHR=3.78; 95% CI: 2.65-5.39). SII showed the strongest association among individuals smoking ≥30 cigarettes/day (AHR=1.39; 95% CI: 1.21-1.60).

Conclusions: Systemic inflammatory markers, particularly SII, were associated with lung cancer risk in Korean men, with stronger associations observed among current smokers. These findings suggest that systemic inflammatory status may help identify individuals at elevated risk of smoking-related lung cancer.

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韩国男性吸烟和饮酒的系统性炎症指数和肺癌风险：韩国癌症预防研究ii的二级数据集分析

全身性炎症与癌症发展有关，但关于其与肺癌风险关联的前瞻性证据仍然有限。本研究评估了韩国男性吸烟状况、饮酒状况及其联合暴露模式下全身免疫炎症指数（SII）和中性粒细胞与淋巴细胞比率（NLR）与肺癌风险的关系。方法：该次要数据集分析利用了韩国癌症预防研究- ii （KCPS-II）的数据，这是一项全国性的前瞻性队列研究。在20167名男性中，在大约14年的中位随访期间发现了236例肺癌病例。使用多变量Cox比例风险模型对人口统计学、生活方式、肝功能和内源性抗氧化生物标志物进行校正，估计SII和NLR每增加1个标准差（SD）导致肺癌的校正风险比（AHRs）。在总体人群中进行分析，并按吸烟和饮酒状况分层，包括同时吸烟和饮酒。结果：较高的SII和NLR与韩国男性肺癌风险增加相关，在当前吸烟者、当前饮酒者和同时吸烟和饮酒的个体中观察到一致的关联。在联合暴露分析中，观察到当前吸烟者炎症标志物水平高的风险显著升高（SII: AHR=3.58; 95% CI: 2.51-5.09; NLR: AHR=3.78; 95% CI: 2.65-5.39）。SII在吸烟≥30支/天的人群中表现出最强的相关性（AHR=1.39; 95% CI: 1.21-1.60）。结论：系统性炎症标志物，特别是SII，与韩国男性肺癌风险相关，在当前吸烟者中观察到更强的相关性。这些发现表明，全身炎症状态可能有助于识别吸烟相关肺癌高风险人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.