Association of Treatment-Related Weight Changes With Functional Impairments, Public Visits, and Future Life Perspectives in Oral Cancer: A Multicenter Study.
Efthymios Papazacharias, Max Lukas Linderkamp, Stephan Alexander Bettag, Anij von der Gracht, Rijahd Sahmer Boustani, Jan Gaessler, Thomas Lewandowski, Fritjof Lentge, Michael-Tobias Neuhaus, Gertrud Krüskemper, Nils-Claudius Gellrich, Philippe Korn, Philipp Jehn
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引用次数: 0
Abstract
Objective: This study aimed to evaluate treatment-related weight changes in oral cancer and examine their association with functional impairments, public visits, and future life perspectives.
Materials and methods: Data from 1359 surgically treated patients were retrospectively analyzed in a multicenter rehabilitation study conducted by the German-Austrian-Swiss Cooperative Group on Tumors of the Maxillofacial Region (DÖSAK). Weight changes were self-reported after treatment using a standardized questionnaire. Associations with tumor stage, surgical treatment, functional impairments, public visits, and future life perspectives were analyzed.
Results: Weight loss was significantly associated with advanced tumor stage (p = 0.001), nodal metastasis (p < 0.001), and radical neck dissection (p = 0.038). Weight differences alone did not change patients' public visits compared with the past (p < 0.001). However, weight loss combined with functional impairments in eating (p < 0.001), speaking (p < 0.001), and physical appearance (p < 0.001) was associated with avoidance of public visits. Stable weight was associated with favorable future life perspectives, whereas weight loss was associated with negative future perspectives (p < 0.001).
Conclusion: Early identification of treatment-related weight changes may help identify patients at risk of functional impairments and adverse psychosocial outcomes, supporting timely nutritional interventions in oral cancer care.
期刊介绍：
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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