Two HIFs, two fates: VHL-HIF signaling controls iNKT cell identity

IF 9.2 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2026-09-09 DOI:10.1016/j.devcel.2026.08.006

Kyung Min Yim,Jin Young Huh,Jae Bum Kim

引用次数: 0

Abstract

Invariant natural killer T (iNKT) cells acquire effector identity during thymic development, yet how metabolic and signaling programs regulate iNKT cell fate remains unclear. In this issue of Developmental Cell, Li et al.1 elucidate that the VHL-HIF axis with HIF1α and HIF2α modulates survival and differentiation of iNKT cells.

查看原文本刊更多论文

两个hif，两种命运：VHL-HIF信号控制iNKT细胞身份

不变自然杀伤T细胞（iNKT）在胸腺发育过程中获得效应细胞身份，但代谢和信号程序如何调节iNKT细胞的命运仍不清楚。在这一期的Developmental Cell中，Li等人1阐明了带有HIF1α和HIF2α的VHL-HIF轴调节iNKT细胞的存活和分化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.