An upside of obesity: Diet-microbe synergy aids immunotherapy

IF 23.2 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2026-09-09 DOI:10.1016/j.chom.2026.08.004

Laura A. Bolte,Johannes R. Björk,Thomas Vogl

引用次数: 0

Abstract

While obesity is generally associated with unfavorable health outcomes, there are notable exceptions. In cancer immunotherapy, epidemiological studies consistently link obesity to improved checkpoint inhibitor responses. Desharnais et al. show in mouse models that this paradox is driven by diet-dependent interactions with the gut microbiome, not obesity itself.

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肥胖的好处：饮食与微生物的协同作用有助于免疫治疗

虽然肥胖通常与不利的健康结果有关，但也有明显的例外。在癌症免疫治疗中，流行病学研究一致将肥胖与检查点抑制剂反应的改善联系起来。Desharnais等人在小鼠模型中表明，这种悖论是由饮食依赖与肠道微生物群的相互作用驱动的，而不是肥胖本身。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.