Association of Reallocation of Movement Behaviours with Ectopic Fat Accumulation: A Cross-Sectional Analysis of the UK Biobank Cohort.

IF 4 2区医学 Q1 SPORT SCIENCES

Medicine and Science in Sports and Exercise Pub Date : 2026-09-07 DOI:10.1249/MSS.0000000000004117

Jiajin Li, Alice E Thackray, James A King, Emily S Petherick, Zhuoxiu Jin, Masashi Miyashita, William Johonson, David J Stensel

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引用次数: 0

Abstract

Purpose: Ectopic fat in non-adipose tissues is linked to higher chronic-disease risk. Using the UK Biobank, this study examined associations of device-measured physical activity (PA) and sedentary time with ectopic fat.

Methods: Liver and pancreas proton density fat fraction (PDFF), and anterior-thigh skeletal muscle fat infiltration (MFI) were assessed by magnetic resonance imaging. Reallocations among accelerometer derived time spent sedentary and in light intensity PA (LPA), and moderate-to-vigorous intensity PA (MVPA) were examined using isotemporal substitution. Multi-variable linear regression was employed with stepwise adjustment for sex, age, height, socioeconomic factors, and counts of cancer and non-cancer illnesses. Sex*activity interaction terms were then added to the models, and sex-stratified analyses were conducted where interactions were significant.

Results: The final sample comprised 9,213 participants with liver PDFF, 6,521 participants with pancreatic PDFF, and 9,197 participants with MFI (mean age ~64 years). Replacing 30 minutes of sedentary time with LPA was associated with lower ectopic fat, with relative percentage differences in fully adjusted models of -2.2% [-2.7%, -1.8%] for liver PDFF, 1.9% [-2.4%, -1.3%] for pancreas PDFF, and -0.5% [-0.7%, -0.4%] for MFI. Substituting sedentary time with MVPA showed greater differences (-9.9% [11.0%, 8.7%], 7.9% [-9.2%, -6.6%], and -3.6 % [-3.9%, -3.2%], respectively). Replacing LPA with MVPA was also associated with lower ectopic fat (-7.6% [-8.9%, -6.4%], -6.0% [7.5%, -4.6%], and -3.0% [-3.4%, -2.6%] for liver PDFF, pancreas PDFF, and MFI. Associations were stronger in females for liver and pancreas PDFF and MFI when sedentary time was replaced with LPA or MVPA.

Conclusions: Reallocation of sedentary time or lower-intensity PA to higher intensity PA is linked to lower ectopic fat. These relationships are stronger in women than men.

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运动行为重新分配与异位脂肪积累的关联：英国生物银行队列的横断面分析。

目的：非脂肪组织中的异位脂肪与更高的慢性疾病风险有关。利用英国生物银行，这项研究检查了设备测量的身体活动（PA）和久坐时间与异位脂肪的关系。方法：采用磁共振成像技术评估肝脏、胰腺质子密度脂肪分数（PDFF）和大腿前骨骼肌脂肪浸润（MFI）。使用等时间替代法检查了加速度计计算的久坐时间、轻强度PA （LPA）和中至剧烈强度PA （MVPA）之间的再分配。采用多变量线性回归，逐步调整性别、年龄、身高、社会经济因素以及癌症和非癌症疾病的数量。然后将性活动相互作用的术语添加到模型中，并在相互作用显著的地方进行性别分层分析。结果：最终样本包括9213名肝脏PDFF患者，6521名胰腺PDFF患者和9197名MFI患者（平均年龄~64岁）。用LPA代替30分钟的久坐时间与较低的异位脂肪相关，在完全调整的模型中，肝脏PDFF的相对百分比差异为-2.2%[-2.7%,-1.8%]，胰腺PDFF的相对百分比差异为1.9% [-2.4%,-1.3%]，MFI的相对百分比差异为-0.5%[-0.7%,-0.4%]。用MVPA代替久坐时间的差异更大（分别为-9.9%[11.0%,8.7%]、7.9%[-9.2%,-6.6%]和- 3.6%[-3.9%,-3.2%]）。肝脏PDFF、胰腺PDFF和MFI用MVPA替代LPA也与较低的异位脂肪相关（-7.6%[-8.9%,-6.4%],-6.0%[7.5%,-4.6%]和-3.0%[-3.4%,-2.6%]）。当久坐时间被LPA或MVPA取代时，女性肝脏和胰腺PDFF和MFI的相关性更强。结论：重新分配久坐时间或低强度PA到高强度PA与降低异位脂肪有关。这种关系在女性中比在男性中更强烈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine and Science in Sports and Exercise 医学-运动科学

CiteScore

7.70

自引率

4.90%

发文量

2568

审稿时长

1 months

期刊介绍： Medicine & Science in Sports & Exercise® features original investigations, clinical studies, and comprehensive reviews on current topics in sports medicine and exercise science. With this leading multidisciplinary journal, exercise physiologists, physiatrists, physical therapists, team physicians, and athletic trainers get a vital exchange of information from basic and applied science, medicine, education, and allied health fields.