To trace or not to trace: analytical insights from network-based contact-tracing models.

IF 2.7 4区 数学 Q2 BIOLOGY
Giulia de Meijere, Andrea Pugliese, Gerardo Iñiguez, Péter L Simon, István Z Kiss
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Abstract

Contact tracing is one of the most important control measures deployed during epidemics and pandemics, relying on the identification of contacts of known infected individuals. A network perspective is therefore essential for its accurate modelling. Pairwise models have been used extensively to study contact tracing, but their analysis typically depends on a decoupling assumption-most commonly that contact tracing operates on a much faster timescale than disease transmission. Furthermore, contact tracing models often assume that each infected individual becomes a contact tracing-triggering node, which is unrealistic given partial compliance to treatment in practice. In this paper, we relax both of these restrictive assumptions and provide a full analytical characterisation of the epidemic threshold in the pairwise mean-field model. Our analysis uses a fast-variables approach that captures the rapid early stabilisation of key network quantities. In addition, inspired by mechanisms from social adoption dynamics, we introduce triplewise contact tracing in which an infected individual can be traced not only through direct contact with a single tracing-triggering neighbor (pairwise tracing), but also indirectly when connected to two tracing-triggering nodes simultaneously. For pure pairwise and pure triplewise contact tracing, we derive analytical expressions for critical contact tracing thresholds and demonstrate that when many infected individuals bypass treatment, the epidemic can become uncontrollable. When both contact tracing mechanisms operate together, we map out their combined contribution and relative impact on epidemic control. This unified framework yields rigorous and tractable threshold conditions for contact tracing dynamics on networks, extending the applicability of pairwise models beyond the fast-tracing regime and providing new insight into the interplay between disease progression, partial treatment compliance, and higher-order tracing processes.

追踪或不追踪:来自基于网络的接触追踪模型的分析见解。
接触者追踪是流行病和大流行期间部署的最重要的控制措施之一,依赖于确定已知感染者的接触者。因此,网络视角对于其精确建模至关重要。成对模型已被广泛用于研究接触者追踪,但它们的分析通常依赖于一个解耦假设——最常见的是,接触者追踪在比疾病传播快得多的时间尺度上运行。此外,接触者追踪模型通常假设每个感染者都成为接触者追踪触发节点,这在实践中部分依从性治疗的情况下是不现实的。在本文中,我们放宽了这两个限制性假设,并提供了两两平均场模型中流行病阈值的完整分析表征。我们的分析使用快速变量方法,捕捉关键网络数量的快速早期稳定。此外,受社会收养动力学机制的启发,我们引入了三重接触追踪,其中感染个体不仅可以通过与单个追踪触发邻居的直接接触(成对追踪)进行追踪,还可以通过同时连接到两个追踪触发节点进行间接追踪。对于纯双接触者追踪和纯三接触者追踪,我们推导了关键接触者追踪阈值的解析表达式,并证明当许多感染者不接受治疗时,疫情可能变得无法控制。当这两种接触者追踪机制同时运作时,我们绘制出它们对疫情控制的综合贡献和相对影响。这种统一的框架为网络上的接触者追踪动态提供了严格且易于处理的阈值条件,将两两模型的适用性扩展到快速追踪机制之外,并为疾病进展、部分治疗依从性和高阶追踪过程之间的相互作用提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.30
自引率
5.30%
发文量
120
审稿时长
6 months
期刊介绍: The Journal of Mathematical Biology focuses on mathematical biology - work that uses mathematical approaches to gain biological understanding or explain biological phenomena. Areas of biology covered include, but are not restricted to, cell biology, physiology, development, neurobiology, genetics and population genetics, population biology, ecology, behavioural biology, evolution, epidemiology, immunology, molecular biology, biofluids, DNA and protein structure and function. All mathematical approaches including computational and visualization approaches are appropriate.
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