Characteristics of Adverse Childhood Experiences and Associations with Adult Autoimmunity and Health-Related Quality of Life.

IF 2.2 Q2 FAMILY STUDIES

Journal of Child & Adolescent Trauma Pub Date : 2026-02-11 eCollection Date: 2026-09-01 DOI:10.1007/s40653-025-00814-x

Bailey J Thompson, Tisha J Ornstein, Karl K Szpunar, Kristin Vickers

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引用次数: 0

Abstract

Adverse childhood experiences (ACE) are associated with negative long-term health consequences, such as autoimmunity. How characteristics of exposure, including types and timing, relate to autoimmunity remains less understood. The objective of the current study is to examine how characteristics of ACE exposure are related to autoimmunity and health-related quality of life (HrQoL). Canadian undergraduate psychology students (N = 643) ages 17 - 40 participated in an online survey. The survey collected on 10-types of adversity, 83 autoimmune symptoms and diseases, and 8 domains of HRQoL, which were analyzed using linear modelling. Participants with clinical ACE exposure reported more autoimmune conditions on average compared to those with nonclinical exposure (β = .33, p < .001). As the severity of the exposure increased, so did the number of reported autoimmune conditions (β = .47, p < .001). The number of different types of exposure was also associated with an increase in autoimmune conditions (β = .37, p < .001), especially among those who had multiple types of exposure. The timing of exposure was related to more autoimmune conditions (β = .26, p < .001), particularly for those with early exposure (ages 0-5) compared to late exposure (ages 9-16, p < .01). Reduced HRQoL was also observed across characteristics of clinical exposure (β range = -.46--.22, p < .001). Exposure to childhood adversity was significantly associated with more autoimmune conditions in adulthood, poor HRQoL, and varied across characteristics of exposure.

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儿童期不良经历的特点及其与成人自身免疫和健康相关生活质量的关系

不良童年经历（ACE）与负面的长期健康后果有关，如自身免疫。暴露的特征，包括类型和时间，与自身免疫的关系尚不清楚。本研究的目的是研究ACE暴露的特征与自身免疫和健康相关生活质量（HrQoL）的关系。643名年龄在17 - 40岁的加拿大心理学本科生参加了一项在线调查。调查收集了10种逆境、83种自身免疫性症状和疾病、8个HRQoL域，并采用线性模型进行分析。与非临床暴露的参与者相比，临床ACE暴露的参与者报告了更多的自身免疫性疾病(β =。33、p β =。47、p β =。37、p β =。p β范围= - 0.46—0.22,p

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来源期刊

Journal of Child & Adolescent Trauma Multiple-

CiteScore

3.00

自引率

6.70%

发文量

期刊介绍： Underpinned by a biopsychosocial approach, the Journal of Child & Adolescent Trauma presents original research and prevention and treatment strategies for understanding and dealing with symptoms and disorders related to the psychological effects of trauma experienced by children and adolescents during childhood and where the impact of these experiences continues into adulthood. The journal also examines intervention models directed toward the individual, family, and community, new theoretical models and approaches, and public policy proposals and innovations. In addition, the journal promotes rigorous investigation and debate on the human capacity for agency, resilience and longer-term healing in the face of child and adolescent trauma. With a multidisciplinary approach that draws input from the psychological, medical, social work, sociological, public health, legal and education fields, the journal features research, intervention approaches and evidence-based programs, theoretical articles, specific review articles, brief reports and case studies, and commentaries on current and/or controversial topics. The journal also encourages submissions from less heard voices, for example in terms of geography, minority status or service user perspectives. Among the topics examined in the Journal of Child & Adolescent Trauma: The effects of childhood maltreatment Loss, natural disasters, and political conflict Exposure to or victimization from family or community violence Racial, ethnic, gender, sexual orientation or class discrimination Physical injury, diseases, and painful or debilitating medical treatments The impact of poverty, social deprivation and inequality Barriers and facilitators on pathways to recovery The Journal of Child & Adolescent Trauma is an important resource for practitioners, policymakers, researchers, and academics whose work is centered on children exposed to traumatic events and adults exposed to traumatic events as children.