When push comes to shove: How chromosomes absorb spindle forces without losing grip.

IF 6.1 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2026-10-05 Epub Date: 2026-09-07 DOI:10.1083/jcb.202608030

Geert J P L Kops

引用次数: 0

Abstract

Chromosomes withstand substantial forces from spindle microtubules prior to their segregation in mitosis. Using super resolution live imaging, Tran, Dumont, and colleagues (https://doi.org/10.1083/jcb.202512154) find that stiff linkages between chromosomes and microtubules coupled with pliable underlying centromeres enables force absorption while maintaining a robust grip on microtubules.

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当推力来推：染色体如何吸收纺锤体力而不失去控制。

在有丝分裂中，染色体在分离前承受纺锤体微管的巨大作用力。通过超分辨率实时成像，Tran、Dumont和同事（https://doi.org/10.1083/jcb.202512154）发现，染色体和微管之间的刚性连接与柔韧的底层着丝粒结合在一起，可以在保持对微管的强大控制的同时吸收力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.