Intranasal xylometazoline hydrochloride to reduce intraoperative nasal hemorrhage in dogs undergoing ala-vestibuloplasty for BOAS: A prospective, randomized study.
Jun-Yan Sek, Arthur House, Theophilus I Emeto, Aaron Carl Chung Lau, Benjamin Mielke
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引用次数: 0
Abstract
Objective: To assess whether intranasal administration of xylometazoline hydrochloride 0.1% reduces intraoperative hemorrhage during ala-vestibuloplasty in dogs undergoing surgical correction for brachycephalic obstructive airway syndrome (BOAS).
Study design: Prospective, randomized, placebo-controlled clinical trial.
Sample population: A total of 30 client-owned brachycephalic dogs undergoing surgery for BOAS with ala-vestibuloplasty.
Methods: Dogs were randomly assigned to receive xylometazoline hydrochloride 0.1% or 0.9% saline intranasally before ala-vestibuloplasty. Total hemorrhage was quantified by weighing cotton-tipped applicators and surgical swabs before and after use. Hemorrhage normalized to bodyweight, percentage estimated blood volume loss, time to hemostasis and rescue hemostatic interventions were recorded.
Results: A total of 17 dogs received xylometazoline and 13 received saline. Median total intraoperative hemorrhage was lower with xylometazoline than saline: 6.27 g, interquartile range (IQR): 4.57-7.45 g versus 16.49 g, IQR: 15.15-25.47 g; p < .0001. This represented a 62% reduction and corresponded to estimated median blood volumes of 5.9 and 15.6 mL, respectively. Hemorrhage normalized to bodyweight was also lower with xylometazoline: 0.69 g/kg versus 1.74 g/kg; p < .0001. Estimated percentage blood-volume loss was lower with xylometazoline: 0.76% versus 1.93%; p < .0001. Median time to hemostasis was shorter with xylometazoline: 14.0 versus 20.0 min; p = .0001. Rescue hemostatic intervention was required in 10/13 saline-treated dogs and 0/17 xylometazoline-treated dogs; p < .001.
Conclusion: Intranasal xylometazoline reduced measured intraoperative hemorrhage and shortened observed time to hemostasis in dogs undergoing ala-vestibuloplasty for BOAS.
Clinical significance: Topical xylometazoline may improve local hemorrhage control and surgical field visibility during ala-vestibuloplasty.
期刊介绍：
Veterinary Surgery, the official publication of the American College of Veterinary Surgeons and European College of Veterinary Surgeons, is a source of up-to-date coverage of surgical and anesthetic management of animals, addressing significant problems in veterinary surgery with relevant case histories and observations.
It contains original, peer-reviewed articles that cover developments in veterinary surgery, and presents the most current review of the field, with timely articles on surgical techniques, diagnostic aims, care of infections, and advances in knowledge of metabolism as it affects the surgical patient. The journal places new developments in perspective, encompassing new concepts and peer commentary to help better understand and evaluate the surgical patient.
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