Deuterium engineering unlocks a tripartite enhancement in a NIR-Ⅱ AIEgen for exceptional cancer theranostics and surgical navigation

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin Pub Date : 2026-10-15 Epub Date: 2026-08-24 DOI:10.1016/j.scib.2026.08.045

Shuo Xiang, Jun Zhu, Caifa You, Yong Tian, Dingyuan Yan, Lei Wang, Dong Wang, Ben-Zhong Tang

引用次数: 0

Abstract

Deuterium engineering is employed to unlock a tripartite enhancement in NIR-Ⅱ AIEgens. This approach simultaneously boosts fluorescence quantum yield, reactive oxygen species (ROS) generation, and physiological stability while retaining photothermal efficiency. The resulting nanoparticles enable trimodal imaging and synergistic phototherapy for complete tumor ablation, and also facilitate high-contrast fluorescence-guided surgical resection of colorectal cancer, significantly prolonging survival in vivo.

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氘工程解锁了NIR-ⅡAIEgen的三重增强，用于特殊的癌症治疗和手术导航。

氘工程用于解锁NIR-ⅡAIEgens的三方增强。该方法在保持光热效率的同时，提高了荧光量子产率、活性氧（ROS）的产生和生理稳定性。由此产生的纳米颗粒使三模成像和协同光疗能够完全消融肿瘤，也有助于高对比度荧光引导的结直肠癌手术切除，显著延长体内生存期。下载：下载高清图片（192KB）下载：下载全尺寸图片

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Bulletin MULTIDISCIPLINARY SCIENCES-

CiteScore

24.60

自引率

2.10%

发文量

8092

期刊介绍： Science Bulletin (Sci. Bull., formerly known as Chinese Science Bulletin) is a multidisciplinary academic journal supervised by the Chinese Academy of Sciences (CAS) and co-sponsored by the CAS and the National Natural Science Foundation of China (NSFC). Sci. Bull. is a semi-monthly international journal publishing high-caliber peer-reviewed research on a broad range of natural sciences and high-tech fields on the basis of its originality, scientific significance and whether it is of general interest. In addition, we are committed to serving the scientific community with immediate, authoritative news and valuable insights into upcoming trends around the globe.