A Highly Robust Y-Based Framework for Sustainable Catalysis and Synthesis of Bioactive Chromeno[2,3-d]Pyrimidin-8-Amine Derivatives.

Abstract

The synthesis of bioactive molecules through one-pot multicomponent reactions under mild conditions is of significant interest for medicinal chemistry, though largely unexplored and challenging. Herein, we have reported a new Y(III)-based chemically stable framework, IITKGP-65, with abundant active catalytic sites, which exhibited excellent stability in open air, water, and even in acidic medium. The activated framework, IITKGP-65a, has been utilized as a Lewis acid-driven heterogeneous catalyst for the synthesis of bioactive chromeno[2,3-d]pyrimidin-8-amine derivatives. Notably, synthesis of these compounds has not yet been reported in the literature using any coordination polymer (CP) or metal-organic framework (MOF)-based catalyst. Interestingly, a good to excellent yield was achieved even with a low catalyst loading of our developed catalyst for a wide range of substrate scopes, along with excellent recyclability without any loss of structural integrity. Most importantly, to demonstrate practical applicability, we synthesized four chromeno[2,3-d]pyrimidin-8-amine derivatives exhibiting antibacterial activity using a green ethanol medium. The facile accessibility, robust structural framework, outstanding catalytic performance, and excellent recyclability collectively underscore the potential of the developed framework, IITKGP-65, as an efficient catalyst. Furthermore, these attributes extend its applicability to the environmentally friendly synthesis of complex bioactive molecules.