Mechanisms of sulbactam-durlobactam resistance in Acinetobacter baumannii.

IF 18.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2026-09-03 DOI:10.1016/j.tim.2026.08.010

Yu Feng, Laurent Poirel, Zhiyong Zong

引用次数: 0

Abstract

Sulbactam-durlobactam is the first-line agent against carbapenem-resistant Acinetobacter baumannii. Resistance can be conferred by metallo-β-lactamases alone or penicillin-binding protein 3 alterations plus β-lactamase overproduction or enhanced efflux. Other reported mechanisms remain associative and resistance in guideline-recommended carbapenem addition is unclear, underscoring the need for mechanistic validation and further studies.

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鲍曼不动杆菌舒巴坦-杜氯巴坦耐药机制。

舒巴坦-杜氯巴坦是抗耐碳青霉烯鲍曼不动杆菌的一线药物。耐药性可由金属β-内酰胺酶单独产生或青霉素结合蛋白3改变加上β-内酰胺酶过量产生或外排增强而产生。其他报道的机制仍然是相关的，指南推荐的碳青霉烯类添加的耐药性尚不清楚，强调了机制验证和进一步研究的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.